Main description:

Antimicrobial resistance (AMR) is a global public health threat that needs immediate attention and action from the scientific community. This book compiles and presents the latest and most important aspects of AMR, including the biology involved, its persistence and spread, and novel approaches to tackle this threat. The book first describes the mechanisms and spread of AMR, and then discusses the various approaches and strategies for combating it.

Important topics include, microbial pathogenesis, AMR traits and major mechanisms underlying drug-resistance and the emerging strategies and technologies for combating AMR. Emphasis has been given on current developments about natural products including potent phyto-molecules, antimicrobial peptides and endophytes effective against the drug-resistant microbes and target the main drug-resistance determinants (efflux pumps, biofilms, quorum sensing, plasmids, etc.) in these bacterial pathogens. Other exciting topics include applications of nanomaterials in tackling AMR and CRISPR-Cas based precise sequence-specific antimicrobials.

This informative book is meant for students and researchers in basic and medical microbiology and biotechnology. It is also useful to public health professionals and industry experts involved in AMR research and related drug-designing.

Contents:

Section I The Mechanisms and Spread of Antimicrobial Resistance
1. Antimicrobial resistance: a global problem with limited answersVinay KumarDepartment of Biotechnology,Modern college, Ganeshkhind, Pune, India; &Department of Environmental Sciences, Savitribai Phule Pune University, Ganeshkhind, Pune, IndiaEmail: vinay.kumar@moderncollegegk.org
2. Antimicrobial resistance in ESKAPE pathogens: an overviewNitaya IndrawattanaDepartment of Microbiology and Immunology,Faculty of Tropical Medicine, Mahidol University,Bangkok, ThailandEmail: nitaya.ind@mahidol.ac.thKarishma PardesiDepartment of Microbiology,Savitribai Phule Pune University, Pune, IndiaEmail: karishma@unipune.ac.in
3. Antimicrobial resistance: from hospital settings to the environmentZulqarnain BalochCollege of Veterinary Medicine,South China Agricultural University,Guangzhou, 510642, ChinaEmail: znbalooch@yahoo.comJohan Bengtsson-PalmeCentre for Antibiotic Resistance Research (CARe),University of Gothenburg, Box 440, SE-40530, Gothenburg, SwedenE-mail: johan.bengtsson-palme@microbiology.se
4. Antimicrobial resistance in agriculture and livestockRonald R MarquardtDepartment of Animal Sciences,The University of Manitoba, Winnipeg MB, CanadaEmail: rr_marquardt@umanitoba.caP. L. MehndirattaDepartment of Microbiology,Maulana Azad Medical College,New Delhi, IndiaEmail: pmehndi@gmail.com
5. Major players involved in spread of antimicrobial resistanceS. Ganesh KumarDepartment of Preventive and Social Medicine,JIPMER, Puducherry, India.E-mail: sssgan@yahoo.comJames A. AyukekbongSection for Clinical Microbiology,Redeem Biomedical, Buea, Cameroon; &Metabiota Inc., Nanaimo, BC, CanadaEmail: ayukjim@yahoo.com
6. An overview of molecular mechanisms underlying antimicrobial resistanceV. DuboisLaboratory of Bacteriology, Bordeaux University Hospital, FranceUniversity of Bordeaux, Bordeaux, FranceEmail: veronique.dubois@u-bordeaux.frM HamzeLaboratoire Microbiologie Sante et Environnement (LMSE),Ecole Doctorale des Sciences et de Technologie,Faculte de Sante Publique, Universite Libanaise, Tripoli, Lebanon.Email: mhamze@monzerhamze.comMuhammad Khalid BashirAnimal Breeding and Genetics,University of Agriculture, Faisalabad, PakistanEmail:mkhalidbashir@uaf.edu.pk
7. Advances in omics approaches for detecting/characterizing antimicrobial resistancePatricia M. G. Paiva,Departamento de Bioquimica, Centro de Biociencias,Universidade Federal de Pernambuco, Pernambuco, BrazilEmail: ppaivaufpe@yahoo.com.brJohn P HaysDepartment of Medical Microbiology & Infectious Diseases,Erasmus University Medical Center (Erasmus MC),Rotterdam, The NetherlandsEmail: j.hays@erasmusmc.nl
8. Alarming drug resistance in urban setupsWei XingKey Laboratory of Aquatic Botany and Watershed Ecology,Wuhan Botanical Garden, Chinese Academy of Sciences,Wuhan 430074, ChinaEmail: xingwei108@wbgcas.cnSayali PatilDepartment of Environmental Sciences,Savitribai Phule Pune UniversityPune, IndiaEmail: sayali.patil@unipune.ac.inAkhand Pratap SinghSchool of Material Science and Technology,Indian Institute of Technology (Banaras Hindu University),Varanasi, IndiaEmail: akhandbiotech@gmail.com
Section II Novel and Alternative Approaches for Tackling Antimicrobial Resistance
9. Emerging trends in developing alternative therapies for combating antimicrobial resistanceRaffaele ZarrilliDepartment of Preventive Medical Sciences,Federico II University of NaplesItalyEmail: rafzarri@unina.itAsad U. KhanInterdisciplinary Biotechnology Unit,Aligarh Muslim University, Aligarh, IndiaEmail: asad.k@rediffmail.comAnthony BoutinDepartment of Emergency Medicine,Nassau University Medical Center,Hempstead Turnpike, East Meadow, NY, United StatesEmail: aboutin@numc.edu
10. Novel medicinal plants/ plant derived molecules for combating antimicrobial resistance via re-potentiating the fading antibiotic arsenalReema GabraniDepartment of Biotechnology,Jaypee Institute of Information TechnologyNoida, IndiaEmail: reema.gabrani@jiit.ac.inJ.S. EswariDepartment of Biotechnology,National Institute of Technology Raipur, IndiaEmail: satyaeswarij.bt@nitrr.ac.inFazlurrahman KhanDepartment of Biotechnology,School of Engineering and Technology,Sharda University, Greater Noida, IndiaEmail: fazlurrahman.khan@sharda.ac.in
11. Potential synthetic treatments for antimicrobial resistant pathogensJaved AliDepartment of Chemical Engineering,Centre for Biological Engineering,Loughborough University, Loughborough,Leicestershire, UKEmail: J.Ali@lboro.ac.ukJohn Cavanagh,Department of Molecular and Structural Biochemistry,North Carolina State University,Raleigh, NC, USA,Email: anavacj@ncsu.edu
12. Application of phytotherapeutics as antibiotic alternatives in animal feedIsabel Blanco-PenedoAnimal Welfare Subprogram, Institute of Agrifood Research and Technology, Girona, SpainEmail: isabel.blanco.penedo@slu.seJoshua GongGuelph Food Research Centre,Agriculture and Agri-Food Canada,Guelph, CanadaEmail: joshua.gong@agr.gc.ca
13. Antimicrobial peptides as effective agents against drug resistant pathogensBhim Pratap SinghDepartment of Biotechnology,Mizoram University, Aizawl, IndiaEmail: bhimpratap@gmail.comMohamed N. SeleemDepartment of Comparative Pathobiology,College of Veterinary Medicine,Purdue University, West Lafayette, USAEmail: mseleem@purdue.edu
14. Essential oils for resensitizing/combating antimicrobial resistanceAnca MironDepartment of Pharmacognosy,Faculty of Pharmacy, University of Medicine and Pharmacy Grigore T. Popa-Iasi, Universitatii, Iasi, RomaniaEmail: ancamiron@yahoo.com or anca.miron@umfiasi.roManuel SimoesLEPABE, Department of Chemical Engineering,Faculty of Engineering,University of Porto, PortugalEmail: mvs@fe.up.ptAbdelhakim BouyahyaaLaboratory of Human Pathologies Biology,Department of Biology, Faculty of SciencesMohammed V University, Rabat, MoroccoE-mail: boyahyaa-90@hotmail.fr
15. Plant secondary metabolites for tackling antimicrobial resistanceSwee-Hua Erin LimHealth Sciences Division, Abu Dhabi Women's College,Higher Colleges of Technology, Abu Dhabi, United Arab EmiratesEmail: erinlim@perdanauniversity.edu.myAbhay Prakash MishraDepartment of Pharmaceutical Chemistry,Hemvati Nandan Bahuguna Garhwal University,Srinagar, Garhwal, IndiaEmail: abhaycimap@gmail.com
16. Microbial secondary metabolites for combating antimicrobial resistanceJolanta SoleckaNational Institute of Public Health - National Institute of Hygiene, Department of Environmental Health and Safety,Warsaw, PolandEmail: jsolecka@pzh.gov.plZhiqiang WangJiangsu Coinnovation Centre for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, ChinaE-mail: zqwang@yzu.edu.cn
17. Phyterapeutics for combating drug efflux pumpsKhondaker M. RahmanInstitute of Pharmaceutical Science,King's College London, Britannia House, London, UKEmail: k.miraz.rahman@kcl.ac.ukRenato FaniDepartment of Biology, University of Florence,Sesto Fiorentino, Florence, ItalyEmail: renato.fani@unifi.it
18. Plant based plasmid curing agents for combating antimicrobial agentsSimon GibbonsResearch Department of Pharmaceutical and Biological Chemistry,UCL School of Pharmacy,London, UKEmail: simon.gibbons@ucl.ac.ukAnja SchufflerInstitute of Biotechnology and Drug ResearchErwin-Schrodinger Strabe, GermanyEmail: schueffler@ibwf.de
19. Anti-quorum sensing agents from natural sources / plantsJohn Thor ArnasonPhytochemistry Laboratory, Department of Biology,University of Ottawa, Ottawa, CanadaEmail: John.Arnason@uottawa.caAna AllendeResearch Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, Campus de Espinardo, Murcia, SpainEmail: aallende@cebas.csic.es
20. Anti-biofilm agents from natural sources / plantsJens RohloffDepartment of Biology, Norwegian University of Science and Technology, Trondheim, NorwayEmail: jens.rohloff@ntnu.noIrena KolouchovaDepartment of Biotechnology,University of Chemistry and Technology, PragueCzech RepublicEmail: irena Kolouchova@vscht.czZaixiang LouState Key Laboratory of Food Science and Technology,School of Food Science and Technology, Jiangnan University, Wuxi,PR ChinaEmail: louzaixiang@126.com
21. Re-sensitization (drug resistance reversal) of drug resistant microbes with phytotherapeuticsRawaa S Al-kayaliDepartment of Biochemistry and Microbiology, Faculty of Pharmacy, University of Aleppo, Syria.Email: rawah67@hotmail.comDr. Ian E. CockEnvironmental Futures Research Institute,Nathan Campus, Griffith University, Nathan,Queensland, Australia.E-mail: I.Cock@griffith.edu.au
22. Functionalized nanomaterials for combating AMRPedro V. Baptista,UCIBIO, Departamento de Ciencias da Vida, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, Caparica, PortugalEmail: pmvb@fct.unl.ptMarta Martins Department of Microbiology, Moyne Institute ofPreventive Medicine, Schools of Genetics and Microbiology, Trinity College Dublin, University of Dublin, Dublin, IrelandEmail:mmartins@tcd.ieSaisubramanian NagarajanCenter for Research in Infectious Diseases,School of Chemical and Biotechnology,SASTRA Deemed to be University, Thanjavur, IndiaEmail: sai@scbt.sastra.edu
23. Exploring in silico approaches for identifying novel antimicrobial agentsT. WeberThe Novo Nordisk Foundation Center for Biosustainability,Technical University of Denmark, Kogle Alle 6, 2970 Horsholm, Denmark.E-mail:tiwe@biosustain.dtu.dkVishwanath TiwariDepartment of Biochemistry,Central University of RajasthanAjmer, IndiaEmail: vishvanath7@yahoo.co.in
24. CRISPR/Cas9-mediated re-sensitization of antibiotic-resistant microbesDae-Hyuk KweonDepartment of Genetic Engineering and Center for Human Interface Nano Technology, Sungkyunkwan University,Suwon, Republic of KoreaEmail: dhkweon@skku.eduMorten H. H. NorholmNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kongens Lyngby, DenmarkEmail: morno@biosustain.dtu.dkStineke van HouteEnvironment and Sustainability Institute, Centre for Ecology and Conservation, University of Exeter, Biosciences, Penryn, Cornwall, United Kingdom,European Centre for Environment and Human Health, University of Exeter Medical School, Knowledge Spa, Royal Cornwall Hospital, Truro, Cornwall, United KingdomEmail: vanhoute.stineke@gmail.com