Main description:

This volume provides an up-to-date account of the achievements pertaining to the application of capsaicin and capsaicin-like molecules in the therapy of various human ailments such as pain, non-allergic rhinitis, obesity, tumors and gastrointestinal, dermatologic and urologic disorders. It discusses the basic functions of the capsaicin receptor (TRPV1), its mechanisms of action and its role in physiological and pathological processes. The text focuses on the most recent progress in the use of capsaicin and capsaicin-like molecules as a therapeutic agent and highlights potential pharmaceutical implications of further TRPV1 research. The chapters are written by noted experts in their fields of endeavor. This book offers both clinicians and researchers valuable resource and reference material on the subject that will stimulate future research.

Contents:

1 Capsaicin and Sensory Neurones: a Historical Perspective

Janos Szolcsanyi

2 Pharmacology of the Capsaicin Receptor, Transient Receptor Potential Vanilloid Type 1 Ion Channel

Istvan Nagy, Dominic Friston, Joao Sousa Valente, Jose Torres Perez, Anna P Andreou

3 TRPV1 in the Central Nervous System: Synaptic Plasticity, Function, and Pharmacological Implications

Jeffrey G. Edwards

4 Topical Capsaicin Formulations in the Management of Neuropathic Pain

Mark Schumacher and George Pasvankas

5 Capsaicin-Based Therapies for Pain Control

Howard Smith and John R. Brooks

6 Intranasal Capsaicin in Management of Non-allergic (Vasomotor) Rhinitis

Umesh Singh and Jonathan A. Bernstein

7 Capsaicin as an Anti-obesity Drug

Felix W. Leung

8 The Potential Antitumour Effects of Capsaicin

Ines Diaz-Laviada and Nieves Rodriguez-Henche

9 Capsaicin as New Orally Applicable Gastroprotective and Therapeutic Drug Alone or in Combination with Non-Steroidal Anti-inflammatory Drugs in Human Healthy Subjects and in Patients

Gyula Mozsik

10 Calcitonin Gene-Related Peptide as Target of Capsaicin Receptor in the Gut

Stefano Evangelista

11 Capsaicin for Osteoarthritis Pain

Laura L. Laslett and Graeme Jones

12 The Role of Capsaicin in Dermatology

Katherine Boyd, Sofia M Shea, James W Patterson

13 Use of Vanilloids in Urologic Disorders

Harris E. Foster, Jr. and Ameuro G. Lake