Main description:

The modern diagnosis and treatment of cancer is intricately tied to the molecular underpinnings of disease. Case Studies in Cancer highlights the broad range of malignancies in which known molecular pathways contribute to tumorigenesis, as well as susceptibility or resistance to therapy. Carefully selected case studies taken from the literature and practice of oncology explain specific examples of cancers and their management in the context of patient-centered case, which expose readers to the broad biological and clinical spectrum of cancer. Examined against the background of historical observations and concepts emerging from research in the molecular biology of cancer, these case studies provide a set of lessons showing how findings at the bench and bedside inform, direct, and inspire each other. Each case is accompanied by take-home points and review questions. Chapter summaries are followed by thought questions and primary and review literature for further reference on the history, biology, and clinical management of oncological disease. This text is appropriate for students starting medical school and those taking advanced courses in cancer biology with a clinical component, as well as practitioners in the field.

Contents:

1. Overview of Cancer and Clinical Oncology

2. Introduction to Cancer Therapy

3. Cytotoxic Chemotherapy

4. Protein Kinase Inhibition

5. Inhibition of the PI3-Kinase/Akt/mTOR Pathway

6. Hormone Therapy

7. Differentiation Therapy

8. Epigenetic Therapy

9. Targeting Protein Degradation and DNA Repair

10. Interference with the Tumor Microenvironment

11. Immunological Strategies: Monoclonal Antibodies

12. Immunological Strategies - Vaccination and Adoptive T-Cell Transfer