Main description:

Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.

Contents:

Part I. Aging and Alzheimer's Disease. The Cholinergic Hypothesis a Generation Later: Perspectives Gained on the Use and Integration of Animal Models, Raymond T. Bartus. Patterns of Cognitive Decline in the Aged Rhesus Monkey, Mark B. Moss, Ronald J. Killiany, and James G. Herndon. Cholinergic Lesions as a Model of Alzheimer's Disease: Effects of Nerve Growth Factor, James M. Conner and Mark H. Tuszynski. The Immunolesioned Animal as a Model of Transmitter Dysfunction, Gary L. Wenk. An Intracerebral Tumor Necrosis Factor-a Infusion Model for Inflammation in Alzheimer's Disease, Kimberly B. Bjugstad and Gary W. Arendash. The Senescence-Accelerated Mouse as a Possible Animal Model of Senile Dementia, Yasuyuki Nomura, Yasunobu Okuma, and Yoshihisa Kitamura. Transgenic Mice Overexpressing Presenilin cDNAs: Phenotype and Utility in the Modeling of Alzheimer's Disease, Karen Duff. Part II. Parkinson's Disease. Intervention Strategies for Degeneration of Dopamine Neurons in Parkinsonism: Optimizing Behavioral Assessment of Outcome, Timothy Schallert and Jennifer L. Tillerson. Development of Behavioral Outcome Measures for Preclinical Parkinson's Research, Mark D. Lindner. Behavioral Assessment in the Unilateral Dopamine-Depleted Marmoset, L. E. Annett, R. E. Smyly, J. M. Henderson, R. M. Cummings, A. L. Kendall, and S. B. Dunnett. Molecules for Neuroprotection and Regeneration in Animal Models of Parkinson's Disease, O. Isacson, L. C. Costantini, and W. R. Galpern. Antisense Knockdown of Dopamine Receptors, Simranjit Kaur and Ian Creese. Is Trophic Factor Gene Disruption a 'Knockout' Model for Parkinson's Disease?, Ann-Charlotte Granholm and Barry Hoffer. Part III. Huntington's Disease. Operant Analysis of Striatal Dysfunction, Peter J. Brasted, Mate D. Doebroessy, Dawn M. Eagle, Falguni Nathwani, Trevor W. Robbins, and Stephen B. Dunnett. Intrastriatal Injections of Quinolinic Acid as a Model for Developing Neuroprotective Strategies in Huntington's Disease, Dwaine F.Emerich. Systemic Administration of 3-Nitropropionic Acid: A New Model of Huntington's Disease in Rat, Emmanuel Brouillet, Philippe Hantraye, and M. Flint Beal. Replicating Huntington Disease's Phenotype in Nonhuman Primates, Philippe Hantraye, Stephane Palfi, Vincent Mittoux, Caroline Dautry, Francoise Conde, and Emmanuel Brouillet. Transgenic Mouse Models of Huntington's Disease, Gillian P. Bates, Laura Mangiarini, and Stephen W. Davies. Part IV. Traumatic Brain Injury and Stroke. Rigid Indentation Models of Traumatic Brain Injury in the Rat, Richard L. Sutton. Rodent Ischemia Models of Embolism and Ligation of the Middle Cerebral Artery: Clinical Relevance to Treatment Strategies of Stroke, Cesario V. Borlongan, Hitoo Nishino, Yun Wang, and Paul R. Sanberg. A Primate Model of Hypertensive Cerebrovascular Disease, Mark B. Moss. Part V. Innovations Leading to Clinical Therapy. Nictotinic Therapeutics for Tourette Syndrome and Other Neuropsychiatric Disorders: From Laboratory to Clinic, R. Doug Shytle, Archie A. Silver, Mary B. Newman, and Paul R. Sanberg. Neural Grafting for Parkinson's and Huntington's Disease, Ben Roitberg, Peter Shin, Joseph Sramek, and Jeffrey H. Kordower. Future Prospects of Gene Therapy for Treating CNS Diseases, Daniel A. Peterson, Jasodhara Ray, and Fred H. Gage. Index.