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MORE ABOUT THIS BOOK
Main description:
Ischemic brain damage represents a major source of morbidity and mortality in westernized society and poses a significant financial burden on the health care system. To date, few effective therapies have been realized. Recent evidence, however, suggests that channels, pumps, and ionic exchangers are involved in CNS ischemia and ischemic stroke, but the potential contribution of these channels for curing stroke is far less understood than for many other normal and pathological conditions. New Strategies in Stroke Intervention: Ionic Channels, Pumps, and Transporters, analyzes the roles played by targets in stroke development and the potential action of drugs modulating these proteins. This book provides a groundbreaking review of these ionic channels, pumps, and transporters as regulators of neuronal ionic homeostasis, providing a better understanding of ischemic brain disorders and the new pharmacological avenues for a cure.
Contents:
Table of Contents:
Preface
Chapter 1. Basis of Ionic Dysregulation in Cerebral Ischemia
Thiruma V. Arumugam, Eitan Okun, and Mark P. Mattson
Chapter 2. Why have ionotropic and metabotropic glutamate antagonists failed in stroke therapy? Gianfranco Di Renzo, Giuseppe Pignataro, Lucio Annunziato
Chapter 3. Mitochondrial channels as potential target for a pharmacological strategies in brain ischemia.
Rosemary H. Milton and Michael R. Duchen
Chapter 4. Endoplasmic Reticulum Calcium Homeostasis and Neuronal Pathophysiology of Stroke
Alexei Verkhratsky
Chapter 5. The Na(+)/Ca(2+) Exchanger: a target for therapeutic intervention in cerebral ischemia
Lucio Annunziato, Pasquale Molinaro, Agnese Secondo, Anna Pannaccione, Antonella Scorziello, Giuseppe Pignataro, Ornella Cuomo, Rossana Strabella, Francesca Boscia, Alessandra Spinali, Gianfranco Di Renzo
Chapter 6. The 'loop' Diuretic Drug Bumetanide-sensitive Na+-K+-Cl - Cotransporter in Cerebral Ischemia
Dandan Sun
Chapter 7. The Na(+)/H(+) exchanger: a target for therapeutic intervention in cerebral ischemia
Jin Xue and Gabriel G. Haddad
Chapter 8. The Na+/K+-ATPase as a drug target for ischemic stroke
Melissa A. Gottron and Donald C. Lo
Chapter 9. Acid-Sensing Ion Channels (ASICs): New Targets in Stroke Treatment
Giuseppe Pignataro
Chapter 10. Role of TRPM7 in Ischemic CNS Injury
Michael F. Jackson, Hong-Shuo Sun, Michael Tymianski, and John F. MacDonald
Chapter 11. Subtypes of voltage-gated Ca2+ channels and ischemic brain injury
Soon-Tae Lee, Daejong Jeon, and Kon Chu
Chapter 12. The diverse roles of K+ channels in brain ischemia
Hiroaki Misonou and James S. Trimmer
Chapter 13. Clinical Trials with Drugs Targeting Ionic Channels, Antiporters, and Pumps in Ischemic Stroke
Alessandra Spinali, Giuseppe Pignataro, Gianfranco Di Renzo, Lucio Annunziato
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2009
Pages: 270
Weight: 626g
Availability: Available
Subcategories: Anaesthetics and Pain, Cardiovascular Medicine, General Issues, Neurology, Neuroscience, Pharmacology
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