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Main description:
Leading neuroscience researchers offer a fresh perspective on neuronal function by examining all its many components-including their pertubation during major disease states-and relate each element to neuronal demands. Topics range from the dependency of neurons on metabolic supply, as well as on both ion and transmitter homeostasis, to their close interaction with the myelin sheath. Also addressed are the astrocytic signaling system that controls synaptic transmission, the extracellular matrix and space as communication systems, the role of blood flow regulation in neuronal demand and in blood-brain barrier function, and inflammation and the neuroimmune system. Insightful and integrative, The Neuronal Environment: Brain Homeostasis in Health and Disease demonstrates a clear new understanding that neurons do not work in isolation, that they need constant interactions with other brain components to process information, and that they are not the only information processing system in the brain.
Contents:
I. Neuronal Activity and Its Dependence on the Microenvironment
Central Nervous System Microenvironment and Neuronal Excitability
Stephen Dombrowski, Imad Najm, and Damir Janigro
Neuronal Energy Requirements
Avital Schurr
II. Brain Microenvironment
Plasticity of the Extracellular Space
Eva Sykova
Transmitter-Receptor Mismatches in Central Dopamine, Serotonin, and Neuropeptide Systems: Further Evidence for Volume Transmission
Anders Jansson, Laurent Descarries, Virginia Cornea-Hebert, Mustapha Riad, Daniel Verge, Mircea Bancila, Luigi Francesco Agnati, and Kjell Fuxe
The Extracellular Matrix in Neural Development, Plasticity, and Regeneration
Jeremy Garwood, Nicolas Heck, Franck Rigato, and Andreas Faissner
Homeostatic Properties of Astrocytes
Wolfgang Walz and Bernhard H. J. Juurlink
Glutamate-Mediated Astrocyte-Neuron Communication in Brain Physiology and Pathology
Micaela Zonta and Giorgio Carmignoto
Axonal Conduction and Myelin
Jeffrey D. Kocsis
Coupling of Blood Flow to Neuronal Excitability
Albert Gjedde
III. Brain Macroenvironment
Choroid Plexus and the Cerebrospinal-Interstitial Fluid System
Roy O. Weller
The Blood-Brain Barrier
Richard F. Keep
Circumventricular Organs
James W. Anderson and Alastair V. Ferguson
Glial Linings of the Brain
Marc R. Del Bigio
IV. Immune System-Neuron Interactions
Microglia in the CNS
Sophie Chabot and V. Wee Yong
Invasion of Ischemic Brain by Immune Cells
Hiroyuki Kato and Takanori Oikawa
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 442
Weight: 930g
Availability: Available
Subcategories: Neuroscience
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