Main description:

This informative book discusses the latest research on the risk factors and therapeutics in dementia. WHO calls dementia a public health priority. Dementia manifests as a group of symptoms associated with decline in memory or other thinking skills and is severe enough to reduce a person's ability to perform everyday activities. It occurs frequently among elderly people, but it is not necessarily part of the normal aging process. The book has been divided into two broad sections. The first section reviews the risk factors involved in developing dementia, including various medical conditions, lifestyle choices, as well as genetics. The latter section describes various therapeutic interventions in dementia. Although there is no known cure for dementia, this book underlines the current treatment strategies that could momentarily reduce the symptoms and improve the quality of life of the patients. This book highlights the global effort to find better ways to halt the progression of dementia and develop novel therapeutic strategies.

The book would be an interesting read for advanced graduate students and researchers working in the field of neuroscience, genetics, and medicine. It will generate good interest to neurologists, psychiatrists, geriatricians, cardiologists, internal medicine practitioners, epidemiologist, and public health workers.

Contents:

Risk Factors

Apolipoprotein E (APOE)

Histone modifications, demethylation, and microRNA regulation

Triggering receptor expressed on myeloid cells 2 (TREM2)

Brain-derived neurotrophic factor (BDNF)

Bridging integrator 1 (BIN1)

Protein tyrosine phosphatase 1B (PTP1B)

Leptin signaling

Insulin signaling

Autophagic dysfunction

Ubiquitin-proteasome system dysfunction

Circadian dysfunction

Endoplasmic Reticulum Stress

Depression

Normal pressure hydrocephalus

Antiphospholipid antibodies

Sex hormones

Changes in blood factors

Infection-induced systemic inflammation

Microbiota

Abdominal visceral fat

Atypical microvascular morphology

Plasma exosomes spread

Changes in visual cortex

Obesity, dyslipidemia, hyperglycemia and hypertension

Environmental pollutions

Therapeutic Interventions

NMDA receptor antagonists

Calcium channel blockers

Catecholamine

Statins

Immunotherapy

Quitting smoking

Physical activity

Diet and nutrition

Natural products as promising drug candidates

Nanotechnological applications

Electroacupuncture

Repetitive transcranial magnetic stimulation

Transcranial direct current stimulation

Reminiscence therapy

Reality orientation therapy

Bright-light therapy

Snoezelen multi-sensory stimulation

Behavioral therapy

Brain-computer interface applications

Music therapy

Hypoxic-hyperoxic training

Cognitive rehabilitation

Cognitive creativity

Stem cell research