Main description:

This updated reference covers diverse aspects of cerebellar development from a full range of viewpoints, including the epidemiology of cerebellar genetic disorders, developmental anatomy, cell biology, genetics, epigenetics, infectious diseases, and mechanisms involved in the regulation of cell fate, while also focusing on information that is relevant to clinicians caring for patients with cerebellar disorders. The chapters are written by experts in the field of cerebellar development, and the chapters cover diseases related to the cerebellum, along with their epidemiology, clinical features, assessment, and management. In addition to updating the content to cover the significant developments in the field since the first edition, the second edition will include new chapters on Non-Coding RNAs and Cerebellar Development, Development of the Fish Cerebellum, the Role of nNOS/NO on Cerebellar Development in Health and Disease, and rehabilitation in cerebellar ataxia. The effect of the COVID-19 on the cerebellum has been included in related chapters. Development of the Cerebellum from Molecular Aspects to Diseases, 2nd edition, is designed to be valuable reference for both neuroscientists and clinicians.

Contents:

1) A historical overview of cerebellar neurodevelopmental disorders; V. Persaud, U of Manitoba, Canada
2) Epidemiology of cerebellar disorders; S. Shooshtari, U of Manitoba, Canada
3) Cerebellar embryology, anatomy, and function; H. Bergen, U of Manitoba, Canada
4) Developmental patterns in the cytoarchitecture of the cerebellum; R. Hawkes, U of Calgary, Canada
5) Developmental disorders of the cerebellum; M. Del Bigio, U of Manitoba, Canada
5) Development of the Fish Cerebellum.
6) Developmental disorders of the cerebellum and GABAergic signaling pathway; G.G. Consalez, San Raffaele Scientific Institute, Italy
7) Developmental disorders of the cerebellum and glutamatergic signaling pathway; S. Ying, Hangzhou University, China
8) Developmental disorders of the cerebellum and cerebellar nuclei neurons; R. Hevner, Seattle Children's Research Institute, USA
9) Developmental disorders of the cerebellum and nerve growth factor signaling pathway; S. Chung, U of Illinois, Chicago, USA
10) Developmental disorders of the cerebellum and glial cells; J. Kong, U of Manitoba, Canada
11) Developmental disorders of the cerebellum and genetics; A. Joyner, New York Memorial Hospital, USA
12) Developmental disorders of the cerebellar afferent and efferent (ataxia); R. Sillitoe, Baylor College of Medicine, USA
13) Developmental disorders of the cerebellum and fetal alcohol syndrome; A. Chudley, U of Manitoba, Canada
14) Developmental disorders of the cerebellum and autism spectrum disorder; H. Fatemi, University of Minnesota Medical School, USA
15) Developmental disorders of the cerebellum and immune system malfunction; A.A. Owji, Shiraz University of Medical Sciences, Iran<
16) Developmental disorders of the cerebellum and Apoptosis, Autophagy, UPR; S. Ghavami, U of Manitoba, Canada
17) Developmental disorders of the cerebellum and ubiquitin proteasome system; J. Vriend, U of Manitoba, Canada
18) Developmental disorders of the cerebellum and mitochondrial damages; M.J. Hosseini, Zanjan University of Medical Sciences, Iran.
19) Developmental disorders of the cerebellum and tumors; T. Klonisch, U of Manitoba, Canada
20) Developmental disorders of the cerebellum and teratogen, toxin, and radiation; A. Chudley, and V Persaud, U of Manitoba, Canada
21) Developmental disorders of the cerebellum and endocrine diseases; N. Koibuchi, Gunma University, Japan
22) Developmental disorders of the cerebellum and infectious diseases; K. Coombs, U of Manitoba, Canada
23) Animal models for the study of developmental disorders of the cerebellum; D. Goldowitz, U of British Columbia, Canada
24) Non-coding RNAs and cellular development.
25) Defining the cerebellar architecture using MRI