Main description:

In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide's physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, including membrane binding, interactions with insulin as well as the interaction between C-peptide and zinc and effects on microvascular vasoreactivity. The third section summarizes in vivo animal studies of the type 1 diabetic complications. The fourth section reviews the clinical efforts of C-peptide on inflammation, cardiovascular complication, neuropathy and nephropathy. Finally, in the Conclusions section, a summary of the present state of C-peptide, outstanding questions, and the likely direction of the field are offered. Developed by the foremost investigators in the rapidly moving field of C-peptide research, Diabetes & C-Peptide: Scientific and Clinical Aspects is an important contribution to the literature for all researchers and physicians concerned about type 1 diabetes.

Contents:

Preface
Foreword

Chapter 1: C-peptide and Insulin - A Happy Marriage
Donald. F. Steiner

Chapter 2: Peptide Interactions of Proinsulin C-peptide
Charlotte Nerelius, Emma Lindahl, Michael Landreh and Hans Joernvall

Chapter 3: The Effect of Combined C-peptide and Zinc on Cellular Function
Dana M. Spence

Chapter 4: C-Peptide Signaling in the Kidney and Protection from Diabetic Nephropathy
Nigel J. Brunskill

Chapter 5: Role of C-Peptide in the Regulation of Microvascular Blood Flow
Thomas Forst, Matthias M. Weber, Thomas Kunt, Andreas Pfutzner

Chapter 6: Is NO-eNOS a target for C-peptide action and its protective effects on diabetic nephropathy?
Kazuhiro Kimura and Akihiro Kamikawa

Chapter 7: Renoprotective Effects of C-Peptide in Type I Diabetes
Lina Nordquist, Asa Kallas, Sara Stridh, Fredrik Palm, John Wahren

Chapter 8: The Mechanisms Underlying the Effects of C-peptide on Type I Diabetic Neuropathy
Hideki Kamiya, Wei-Xian Zhang, Anders A.F. Sima

Chapter 9: C-peptide and Type 1 Diabetic Encephalopathy
Anders A.F. Sima, Wei-Xian Zhang

Chapter 10: C-peptide: a New Molecule with Anti-Inflammatory Properties
Jaime Haidet, Vincenza Cifarelli, Xuehui Geng, Massimo Trucco, Patrizia Luppi

Chapter 11: C-peptide: Connecting Diabetes with Macrovascular Complications
Karen E. Porter, Romana S. Mughal

Chapter 12: C-peptide and Diabetic Neuropathy in Patients with Type I Diabetes
Karin Ekberg, John Wahren

Chapter 13: Proatherogenic Effects of C-Peptide
Daniel Walcher, Nikolaus Marx

Chapter 14: Conclusions and Future Outlook
Anders A.F. Sima