Main description:

Diabetes, particularly type 2, has become increasingly more common around the world. Consequently, the effect of diabetes on the brain has achieved enormous public health importance. A surge in pre-clinical and clinical research on topics ranging from management of hyperglycemia in acute stroke to disturbances in insulin signaling in Alzheimer's disease has led to substantial progress in the field. Written by a panel of international experts, Diabetes and the Brain provides in depth reviews on the cerebral complications of diabetes, and offers introductory chapters on current insights on the pathophysiology and clinical management of diabetes, as well as neuropsychological assessment and dementia. This relevant and easily accessible book explains the cerebral complications of diabetes, with an update on diabetes for neurologists, psychiatrists, and mental health providers and researchers in general,and on stroke and dementia for those involved in research and clinical practice in diabetes.

Contents:

Section 1 update on diabetes for neurologists
1. Type 1 diabetes
(epidemiology, diagnosis, co-morbidity-complications, management)

2. Type 2 diabetes
(epidemiology, diagnosis, co-morbidity-complications, management)

Section 2 update on stroke and dementia for diabetologist
1. Acute ischemic stroke
(epidemiology, diagnosis, co-morbidity-complications, acute treatment, secundary prevention)
Dr HB vand der Worp
Department of Neurology, G03.228
University Medical Center
PO Box 85500
3508 GA Utrecht
the Netherlands

2. Neuropsychological assessment
Dr Augustina MA Brands, Prof Edward HF de Haan
Department of Neurology, G03.228
University Medical Center
PO Box 85500
3508 GA Utrecht
the Netherlands

3. Clinical evaluation of cognitive dysfunction and dementia
Prof. Philip Scheltens
Dept. Neurology / Alzheimer Center
VU University Medical Center
email: p.scheltens@vumc.nl

4. Current treatmet of cognitive dysfunction and dementia

Section 3: Acute cerebral disturbances in diabetes

1. Hypoglycemia
Professor Brian M. Frier,
Department of Diabetes, Royal Infirmary of Edinburgh,
51 Little France Crescent,
Edinburgh, EH16 4SA, UK. E-mail: brian.frier@luht.scot.nhs.uk

2. Ketoacidosis and hyperglycemic hyperosmolar state

3. Diabetes and stroke
Professor Boris N Mankovsky
Institute of Endocrinology,
Kiev,
Ukraine
mankovsk@uprotelnetua

4. Hyperglycemia in acute stroke
Nyika D Kruijt, Y Roos,
Department Neurology Academic Medical Center
University of Amsterdam
P.O. Box 22700
1100 DE Amsterdam
The Netherlands N.D.Kruijt@amc.uva.nl

Section 4: Long term cerebral complications in diabetes
Section 1: clinical observations
Each chapter should include a clear description of the nature and severity of cognitive/behavioural changes, relate function to brain structure, describe risk factors and possible treatment options and provide a clear statement on implications for daily clinical care

1. Cognition in children with type 1 diabetes
Professor Christopher M. Ryan
Department of Psychiatry,
University of Pittsburgh School of Medicine,
Pittsburgh, PA USA
ryancm@upmc.edu

2. Cognition in adults with type 1 diabetes
Professor Ian J Deary
Department of Psychology,
University of Edinburgh,
Edinburgh, U.K.
I.Deary@ed.ac.uk

3. Cognition in type 2 diabetes and in pre-diabetic stages
Esther van den Berg
Department of Neurology, G03.228
University Medical Center
PO Box 85500
3508 GA Utrecht
the Netherlands

4. Diabetes and dementia
Jose A. Luchsinger, MD MPH
Assistant Professor of Medicine
Columbia University
PH9E-105
630 West 168th Street
New York, NY 10032
jal94@columbia.edu

5. Diabetes and depression
Professor Patrick J. Lustman, PhD,
Department of Psychiatry,
Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8134,
St. Louis, MO 63110. E-mail: lustmanp@wustl.edu

6. Central nervous system involvement in painful diabetic neuropathy
Professor Solomon Tesfaye MD FRCP
Consultant Physician/Honorary Professor of Diabetic Medicine (University of Sheffield),
Royal Hallamshire Hospital,
Glossop Road,
Sheffield S10 2JF, UK
e mail: solomon.tesfaye@sth.nhs.uk

Section 5: e