Main description:

Diabetes mellitus has become epidemic on a global scale, and millions of new cases are diagnosed every year. The epidemic of diabetes mellitus is expected to result in one of the steepest rises in human morbidity and mortality ever observed outside of wartime. Insulin resistance is a hallmark of pre-diabetes and type 2 diabetes mellitus, and is characterized by impaired insulin-signaling transduction. Authoritative and comprehensive, Lipoproteins in Diabetes Mellitus details the many changes wrought by insulin resistance and diabetes mellitus on lipid and lipoprotein metabolism. The book begins by summarizing the various techniques to measure lipoproteins and their subclasses. The mechanisms by which insulin resistance and diabetes mellitus increase risk for atherosclerosis, diabetic retinopathy, and diabetic nephropathy are then explored in detail. Finally, the effects of lifestyle modification and the results of clinical trials using established and investigational drugs are discussed.

An invaluable contribution to the literature, Lipoproteins in Diabetes Mellitus is a comprehensive reference on the clinical and scientific aspects of lipoproteins in diabetes. It will have a long-lasting and significant effect on the medical management of people with diabetes.

Contents:

Ch1: Laboratory Assessment of Lipoproteins in Diabetes

David R. Sullivan

Barry Lewis

Ch2: Lipoprotein Subclasses and Cardiovascular Disease Risk in Insulin Resistance Diabetes

Michael Cobble

Patrick D. Mize

Eliot A. Brinton

Ch3: Insulin Resistance and Atherosclerosis

Kamalpreet Singh

Vasudevan A. Raghavan

Ch4: Apoproteins and Cell Surface Receptors Regulating Lipoprotein Metabolism in the Setting of Type 2 Diabetes

Thomas D. Dayspring

Ch5: Lipoprotein Metabolism and Alterations induced by insulin resistance and diabetes

Gerald H. Tomkin

Daphne Owens

Ch6: Production and Metabolism of Triglyceride-Rich Lipoproteins in both the Normal and Diabetic States

Angela Pirillo

Giuseppe D. Norata

Alberico L. Catapano

Ch7: Lipoprotein(a): Structure, Metabolism and Pathophysiology

Alicia J. Jenkins

Karam M. Kostner

Gerhard M. Kostner

Ch8: Lipoprotein Glycation in Diabetes Mellitus

Alicia J. Jenkins

Richard L. Klein

Andrzej S. Januszewski

Ch9: Lipoprotein (LDL and HDL) Oxidation in Diabetes Mellitus

Marielle Kaplan

Michael Aviram

Tony Hayek

Ch10: The Role of Modified Forms of LDL and Corresponding Autoantibodies in the Development of Complications in Diabetes

Maria F. Lopes-Virella

Gabriel Virella

Ch11: Lipid - Extracellular Matrix Interactions as Therapeutic Targets in the Atherosclerosis of Diabetes

Narin Osman

Peter J.

Little

Ch12: Tools for Assessing Lipoprotein Metabolism in Diabetes Mellitus

Richard L. Klein

Ch13: Endothelial Dysfunction and Dyslipidaemia in Type 2 Diabetes: Pathogenesis, Significance and Therapy

Sandra J. Hamilton

Gerald F. Watts

Ch14: Lipoproteins and Diabetic Nephropathy

Ville-Petteri Makinen

Nina Tolonen

Per-Henrik Groop

Ch15: Roles of Extravasated and Modified Plasma Lipoproteins in Diabetic Retinopathy

Mingyuan Wu

Timothy J. Lyons

Ch16: Effects of Lifestyle (Diet, Plant Sterols, Excercise) and Glycemic Control on Lipoporteins in Diabetes

Peter Clifton

Ch17: About Randomised Clinical Trials Related to Lipoproteins in Diabetes Mellitus

Anthony Keech

Alicia J. Jenkins

Val Gebski

Ch18: Statin Therapy: Impact on Dyslipidemia and Cardiovascular Events in Diabetic Patients

Seth S. Martin

Parag H. Joshi

Steven R. Jones

Ch19: The PPAR System in Diabetes

Jean Claude Ansquer

Christelle Foucher

Ch20: Fibrate Therapy: Impact on Dyslipidemia and Cardiovascular Events in Diabetic Patients

Eliot A. Brinton

Ch21: Niacin Therapy: Impact on Dyslipidemia and Cardiovascular Events in Diabetic Patients

Henry A. Tran

Arthur Z. Schwartzbard

James A. Underberg

Ch22: Cholesterol Absorption Inhibitors (Ezetimibe) and Bile Acid Binding Resins (Colesevelam HCl) as Therapy for Dyslipidemia in Patients with Diabetes Mellitus

Harold Bays

Ch23: Emerging Lipoprotein-Related Therapeutics for Patients with Diabetes

Peter J. Little

Alan Chait

Andrzej S. Januszewski

Alex Bobik

David O'Neal

Alicia J. Jenkins