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Gene and Cellular Immunotherapy for Cancer
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Main description:

Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more.

Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field.


Contents:

Part I: Overview

1. The History of Cellular Therapies

2. Basics of Immunity

Part II: CAR-T

3. Biology of CAR-T

4. Cell Types Used for CAR-T Generation

5. Combination Therapeutics with CAR-T Cell Therapy

6. Safety Switches Used for Cellular Therapies

7. Off the Shelf CAR-T

8. Manufacturing of CAR-T Cells: the Assembly Line

9. Navigating Regulations in Gene and Cell Immunotherapy

10. Bringing CAR-T to the Clinic

11. CAR-T Cell Complications

12. Mechanisms of Resistance and Relapse after CAR-T Cell Therapy

Part III: TIL

13. Tumor Infiltrating Lymphocytes (TIL): From Bench to Bedside

Part IV: TCR

14. T-cell Receptor (TCR) Engineered Cells and Their Transition to Clinic

Part V: Viral CTLs

15. Viral Cytotoxic T Lymphocytes (CTLs): from Bench to Bedside

Part VI: NK Cell

16. Biology of NK Cells and NK Cells in Clinic

Part VII: T/NK cell engagers

17. Biology and Clinical Evaluation of T/NK Cell Engagers

Part VIII: Logistics

18. Roadmap for Starting an Outpatient Cellular Therapy Program


PRODUCT DETAILS

ISBN-13: 9783030878511
Publisher: Springer (Springer Nature Switzerland AG)
Publication date: December, 2022
Pages: 378
Weight: 593g
Availability: Available
Subcategories: Microbiology, Oncology, Pharmacology

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