Main description:

This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.

Contents:

The Biology of Toll-like Receptors and NOD-like Receptors: Toggles of Inflammation.- Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword.- Structural Genomic Variation in Toll-Like Receptor 4 and Cancer.- Structural Genomic Variation in Other Toll-like Receptors and Cancer.- Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer.- Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer.- Structural Genomic Variation in NOD-Like Receptors and Cancer.- Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases.- Hot Spots In the Field: Where Should We Go.