Main description:

Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path.

Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues.

Contents:

1. Insights on Nervous System Biology and Anatomy
2. Introduction to Neurodegenerative Diseases
3. Introduction to Trauma in CNS
4. Impact of Neuro-inflammation in Injury and Disease in the CNS
5. Current Clinical Approaches in Neurodegenerative Diseases
6. Neuroprotection in the Injured Spinal Cord
7. Immunomodelatory Approaches for Tackling Neuro-Inflammation
8. Role of Fetal and Adult Tissues in CNS Regenerative Medicine
9. Adult Stem Cells' Therapeutic Potential for Injured CNS
10. iPSCs: An Essential Toolkit for Repair and Regeneration of the CNS?
11. Biomaterial-Based Systems as Biomimetic Agents in the Repair of the CNS
12. Tissue Engineering and Regenerative Medicine in CNS Repair
13. New Trends in Drug Delivery in CNS Regeneration
14. Gene Therapy Approaches in CNS Regenerative Medicine
15. Gene Editing and CNS Regeneration
16. Molecular Therapies in Neurodegeneration and Injury
17. Deep Brain Stimulation and Parkinson's Disease
18. Brain-Spinal Cord Interfaces
19. Electroceuticals
20. Secretome of Cells and Its Role in Neuroregeneration
21. 3D Organoids and Bioreactors
22. Microfluidics and Lab-on-a-Chip
23. Translational Research: From Proof of Concept to Clinical Trials
24. Advanced Therapies Medicinal Products
25. Animal Models of CNS Disorders
26. Bioethics in Translation Research and Clinical Trials