Main description:

This book describes the role of heat shock proteins in the life cycle of malaria parasites. The work includes a general introduction on the structural and functional features of heat shock proteins. The main focus is on the role of heat shock protein families from Plasmodium falciparum, their role in protein folding and in the development of malaria pathology. The functions of individual families of heat shock proteins from plasmodium species and their cooperation in functional networks is described. Subcellular and extracellular organelles such as the apicoplast and the Maurer’s Clefts which are associated with plasmodium species, are discussed in detail. The role of heat shock proteins in the development and function of these organelles structures are highlighted. Although conceding that heat shock proteins may not be ideal antimalarial drug targets, prospects of targeting heat shock proteins in antimalarial drug discovery either directly and/or in combination therapies are explored.

Feature:

This is a novel area of malaria research that is very topical

All of the chapters are written by leaders or experts in the field

The chapters on drug discovery will appeal to the biotechnology industry

Back cover:

This book describes the role of heat shock proteins in the life cycle of malaria parasites. The work includes a general introduction on the structural and functional features of heat shock proteins. The main focus is on the role of heat shock protein families from Plasmodium falciparum, their role in protein folding and in the development of malaria pathology. The functions of individual families of heat shock proteins from plasmodium species and their cooperation in functional networks is described. Subcellular and extracellular organelles such as the apicoplast and the Maurer’s Clefts which are associated with plasmodium species, are discussed in detail. The role of heat shock proteins in the development and function of these organelles structures are highlighted. Although conceding that heat shock proteins may not be ideal antimalarial drug targets, prospects of targeting heat shock proteins in antimalarial drug discovery either directly and/or in combination therapies are explored.

Contents:

1. Introduction: The importance of molecular chaperones in survival and pathogenesis of the malaria parasite Plasmodium  falciparum (Jude Przyborski)

2. General structural and functional features of molecular chaperones (Adrienne Edkins & Aileen Boshoff)

3. The role of Hsp70s in the development and pathogenicity of Plasmodium species (Addmore Shonhai)

4. Role of the Hsp40 family of proteins in the survival and pathogenesis of the malaria parasite (Eva-Rachele Pesce, Alexander G Maier & Gregory L Blatch)

5. Role of Hsp90 in Plasmodium falciparum malaria (Dea Shahinas, Dylan R. Pillai)

6. The role of parasite heat shock proteins in protein trafficking and host cell remodelling

(Sarah C. Charnaud,  Brendan S. Crabb & Paul R. Gilson)

7. Role of heat shock proteins in immune modulation in malaria (Evelyn Böttger & Gabriele Multhoff)

8. Establishment of Plasmodium falciparum extracellular compartments in its host erythrocyte

(Alassane Mbengue, Laurence Berrye and Catherine Braun-Breton)

9. Chaperones and Proteases of Plasmodium falciparum (Kaiyin Liu & Walid A. Houry)

10. Heat shock proteins as targets for novel anti-malarial drugs  (Manish Grover, Shweta Chaubey & Utpal Tatu)

11. What do we know, what do we not know, and what should the future focus be? (Addmore Shonhai & Gregory L Blatch)