Main description:

This new edition describes the role of heat shock proteins in the life cycle of malaria parasites, particularly in the context of intracellular parasite stages. Thoroughly revised, this work provides a general introduction to the structural and functional features of heat shock proteins with a special focus on their role as molecular chaperones in ensuring protein quality control. The emphasis is on the heat shock protein families from Plasmodium falciparum, and their role in proteostasis and the development of malaria pathology. Moreover, the authors explore the latest prospects of targeting heat shock proteins in antimalarial drug discovery either directly or in combination therapies.
Readers will experience a functional analysis of the individual families of heat shock proteins and their cooperation in functional networks, including both the parasite-resident proteome and the exportome released into host cells during intracellular stages. Subcellular and extracellular organelles such as the apicoplast and the Maurer's Clefts associated with Plasmodium species are discussed in detail. The book highlights the role of heat shock proteins in the development and function of these structures.
Biochemical expertise and the inclusion of novel therapeutic solutions make this collection a unique reference for experts in heat shock protein research, parasitology and infectious diseases, cell stress, molecular biology and drug discovery. Not least, advances in malaria control will contribute to ending epidemics and ensuring healthy lives in line with the UN Sustainable Development Goals.

Contents:

*Emails and affiliation only provided for corresponding authors*
PrefaceAcknowledgements

Contributors

About the Editors

1. The Importance of Molecular Chaperones in Survival and Pathogenesis of the Malaria Parasite Plasmodium falciparumJude Przyborski (jude.przyborski@ernaehrung.uni-giessen.de)University of Giessen, Germany (JP)
2. General Structural and Functional Features of Molecular ChaperonesAdrienne L. Edkins (a.edkins@ru.ac.za) and Aileen Boshoff (a.boshoff@ru.ac.za)Rhodes University, South Africa (ALE and AB)
3. The Role of Hsp70s in the Development and Pathogenicity of Plasmodium SpeciesAddmore Shonhai (Addmore.Shonhai@univen.ac.za)University of Venda, South Africa (AS)
4. Role of the Hsp40 Family of Proteins in the Survival and Pathogenesis of the Malaria ParasiteTanima Dutta, Eva-Rachele Pesce, Alexander G. Maier (alex.maier@anu.edu.au) and Gregory L. Blatch (g.blatch@ru.ac.za)Australian National University, Australia (AGM)Rhodes University, South Africa (GLB)
5. Role of Hsp90 in Plasmodium falciparum Malaria Dea Shahinas (dea.shahinas@alum.utoronto.ca) and Dylan R. Pillai (drpillai@ucalgary.ca)University of Toronto, Canada (DS)The University of Calgary, Canada (DRP)
6. The Role of Parasite Heat Shock Proteins in Protein Trafficking and Host Cell Remodeling Sarah C. Charnaud, Brendan S. Crabb and Paul R. Gilson (paul.gilson@burnet.edu.au)Burnet Institute, Australia (PRG)
7. Role of Heat Shock Proteins in Immune Modulation in MalariaTawanda Zininga (tzininga@sun.ac.za), Evelyn Boettger and Gabriele Multhoff (gabriele.multhoff@tum.de)Stellenbosch University, South Africa (TZ)Technische Universitat Munchen, Germany(GM)
8. Establishment of Plasmodium falciparum Extracellular Compartments in its Host ErythrocyteTawanda Zininga (tzininga@sun.ac.za), Alassane Mbengue, Laurence Berry and Catherine Braun-Breton (cbb@univ-montp2.fr)University of Montpellier, France (CB-B)
9. Bioprospecting for Novel Heat Shock Protein Modulators: The New Frontier for Anti-Malarial Drug Discovery?Chinedu P. Anokwuru (anokwuruchi@gmail.com), Stanley Makumire (stanmakster@gmail.com), Addmore Shonhai (addmore.shonhai@univen.ac.za)Tshwane University of Technology, South Africa (CPA)University of Cape Town, South Africa (SM)University of Venda, South Africa (AS)
10. Heat Shock Proteins as Targets for Novel Anti-Malarial Drug DiscoveryMichael O. Daniyan (mdaniyan@oauife.edu.ng)Obafemi Awolowo University, Nigeria (MOD)
11. Heat Shock Proteins of Malaria: What Do We Not Know, and What Should the Future Focus Be? Addmore Shonhai (Addmore.shonhai@univen.ac.za) and Gregory L. Blatch (g.blatch@ru.ac.za)University of Venda, South Africa (AS)Rhodes University, South Africa (GLB)
Index