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MORE ABOUT THIS BOOK
Main description:
In the summer of 1988, my developmental biology professor announced to the class that hematopoietic stem cells (HSCs) had finally been purified. Somehow, I never forgot the professor's words. When I started working in Dr. Irv Weissman's labo- tory at Stanford as a postdoctoral fellow, I realized that the findings mentioned by the professor were from Weissman's laboratory and had been published in a 1988 edition of the journal Science. It has been over 20 years since the publication of that seminal paper, and since then tremendous advances in understanding the biology and maturation of HSCs, namely the process of hematopoiesis, which includes lymphocyte development, have been made. These discoveries were made possible in part by advancements in technology. For example, recent availability of user friendly fluorescence activated cell sorting (FACS) machines and monoclonal an- bodies with a variety of fluorescent labels has allowed more scientists to sort and analyze rare populations in the bone marrow, such as HSCs. All classes of hematopoietic cells are derived from HSCs. Stem cell biology draws enormous attention not only from scientists, but also from ordinary people because of the tremendous potential for development of new therapeutic application to diseases that currently lack any type of effective therapy. Thus, this type of "regenerative medicine" is a relatively new and attractive field in both basic science and clinical medicine.
Contents:
List of Contributors
Acknowledgement
Preface
Chapter 1
Principles of hematopoietic Stem Cell Biology
Hideo Ema, Toshihiro Kobayashi, and Hiromitsu Nakauchi
Chapter 2
Hematopoietic Stem Cells and Their Niche
Hiroko Iwasaki and Toshio Suda
Chapter 3
Hematopoietic Stem Cells and Somatic Stem Cells
Kah Yong Tan, Francis S. Kim, Amy J. Wagers, and Shane R. Mayack
Chapter 4
Developmental Biology of Mammalian T cell progenitors: From Early Lymphoid Progenitors to Thymus-Colonizing Cells
Sophie Ezine, Laetitia Gautreau, Aude Parcelier and Bruno Canque
Chapter 5
GATA-1 and GATA-2 functions in hematopoietic differentiation
Takashi Moriguchi, Mikiko Suzuki, James Douglas Engel, and Masayuki Yamamoto
Chapter 6
Role of the IL-7 Receptor in T Cell Development from Hematopoietic Stem Cells
Koichi Ikuta and Shizue Tani-ichi
Chapter 7
Dendritic cell homeostasis - physiology and impact on disease
Miriam Merad and Markus G. Manz
Chapter 8
Wnt in hematopoietic and leukemic stem cells
Kim-Hien T. Dao and Catriona H. M. Jamieson
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: December, 2009
Pages: 266
Weight: 620g
Availability: Available
Subcategories: Haematology, Immunology
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