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Main description:
This text highlights the endogenous regenerative potential of the central nervous system in neonates and juveniles and discusses possible ways it might be manipulated for medical purposes. The first section provides a descriptive summary of the salient steps of human brain development with a discussion of comparisons with other mammalian brains. It also provides a historical perspective on our understanding of ongoing brain development throughout the lifespan and serve to introduce the concept of brain plasticity following injury. The second part is devoted to the endogenous reparative potential of the brain, including its limitations, and articles focusing on defined pathologies (e.g. anoxia/hypoxia, epilepsy, traumatic brain injury and stress) in animal models and in humans pinpoint eventual ways these pathologies might be manipulated. The third and final focuses on the "dark side" of stem cells for brain repair or of the manipulation of spontaneous adaptive events after injury (e.g. genomic instability, sensitization to cancerous transformation and defective neural networks).
Contents:
.-1 Introduction
.-Marie-Pierre Junier, Steven G. Kernie
.-2 Structural Plasticity in Adult Nervous System: A Historic Perspective
.-Constantino Sotelo, Isabelle Dusart
.-3 Impact of Injured Tissue on Stem Cell Fate
.-Bobbi Fleiss, Vibol Chhor, Luigi Titomanlio, Stephane Auvin, Olivier Baud, Pierre Gressens
.-4 Role of Neural Stem and Progenitor Cells in the Adaptation of the Brain to Injury
.-Sue Hong, Tzong-Shiue Yu, Steven G. Kernie
.-5 Role of Adult Neurogenesis in Seizure-Induced Hippocampal Remodeling and Epilepsy
.-Alison L. Althaus, Jack M. Parent
.-6 Neurogenesis and Gliogenesis in the Postnatal Hypothalamus: a new level of plasticity for the regulation of hypothalamic function?
.-Ariane Sharif, Sergio R. Ojeda, Vincent Prevot
.-7 Regenerative Potential of NG2 Cells
.-Jean-Marie Mangin
.-8 Oligodendrocyte Progenitors and Brain Remodeling Following Blood Brain Barrier Rupture
.-Praveen Ballabh
.-9 Genomic Integrity of Embryonic and Neural Stem Cells
.-Nathalie Lefort, Marc Peschanski
.-10 Links Between Injury-Induced Brain Remodeling and Oncogenesis?
.-Marie-Pierre Junier, Elias A. El-Habr
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: February, 2014
Pages: 202
Weight: 5287g
Availability: Available
Subcategories: Neurology, Neuroscience, Oncology
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