Main description:

Despite recent advances, therapeutic efforts have not been successful establishing a definitive strategy of treatment for brain gliomas, because of the presence of the blood-brain barrier. Innovative Brain Tumor Therapy presents a synopsis of the studies on nanoparticles as ideal devices for brain tumor treatment. Their nanometric size, electrostatic charge, and lipophilic characteristics allow them to penetrate into the brain tissue freely. Promising in-vitro results have been reported, but remain to be validated in humans. This title focuses on the blood-brain barrier pathophysiology in brain tumors, and the possibilities of overcoming this with nanoparticle-based systems. Relevant patents of nanoparticles used as drug delivery carriers are also reported, as well as future scenarios in nanoparticles and stem cells.

Contents:

List of figures
List of abbreviations
About the authors
Introduction
1: Brief introduction on brain tumor epidemiology and state of the art in therapeutics

Abstract

2: Blood-brain barrier pathophysiology in brain tumors

Abstract

3: Brain drug-delivery attempts

Abstract

4: Nanoparticles potential: types, mechanisms of action, actual in vitro and animal studies, recent patents

Abstract
4.1 Nanomedicine and nanoparticles: general overview
4.2 Main types of nanoparticles for drug-delivery systems
4.3 Application in brain tumors
4.4 Recent patents in brain tumors
4.5 Nanotechnology

5: Future scenarios: nanoparticles and stem cells

Abstract

6: Conclusions
Index