Main description:

Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book.

Contents:

1. Multiple Sclerosis. Clinical course, open questions, unmet clinical needs
2. CNS Imaging in Multiple Sclerosis
3. Biomarkers in Multiple Sclerosis
4. Pre-clinical Models of Multiple Sclerosis
5. iPSC Models to Study Multiple Sclerosis
6. T cells in Multiple Sclerosis
7. B cells in Multiple Sclerosis
8. Antibodies in Multiple Sclerosis
9. Microglia in Multiple Sclerosis
10. Peripheral myeloid cells in Multiple Sclerosis
11. Antigen Presenting Cells in Multiple Sclerosis
12. Oligodendrocytes in Multiple Sclerosis
13. Astrocytes in Multiple Sclerosis
14. The Blood Brain Barrier in Multiple Sclerosis
15. Brain Lymphatics in Multiple Sclerosis
16. Mechanisms of Neurodegeneration in Multiple Sclerosis
17. Microbiome in Multiple Sclerosis
18. Genetics of Multiple Sclerosis
19. Environmental Factors in Multiple Sclerosis
20. Novel Therapies for Multiple Sclerosis