Main description:

The enormity of the global healthcare costs vical. One-fifth of all cancers worldwide as a result of cancer infliction cannot be are caused by a chronic infection, for overemphasized. There are more than 100 example, human papilloma virus (HPV) types of cancers; any part of the body can causes cervical cancer and hepatitis B be affected. More than 11 million people virus (HBV) causes liver cancer. Tobacco are diagnosed with cancer every year, and use is the most common preventable cause it is estimated that there will be 16 mil- of cancer in the world. Approximately, lion new cases per year by the year 2020. 168,000 cancer deaths are expected to be In 2005, 7. 6 million people died of can- caused by tobacco use. Approximately, cer, that is, 13% of the 58 million deaths 40% of cancer could be prevented, mainly worldwide. It is estimated that 9 million by not using tobacco, having a healthy people will die from cancer worldwide in diet, being physically active, preventing 2015 and 11. 4 million will die in 2030. infections that may cause cancer, reduc- More than 70% of all cancer deaths occur ing exposure to sunlight, and avoidance of in low and middle income countries. excessive alcohol consumption and stress Five major cancer causing overall mor- (anger). A third of cancers could be cured talities per year worldwide are (WHO): if detected early and treated adequately. It is well established that scientific 1. Lung: 1.

Contents:

1. BREAST CANCER: COMPUTER-AIDED DETECTION Bin Zheng INTRODUCTION
DEVELOPMENT OF COMPUTER-AIDED DETECTION SCHEMES
EVALUATION OF COMPUTER-AIDED DETECTION SCHEME PERFORMANCE
APPLICATION OF COMPUTER-AIDED DETECTION SCHEMES TO CLINICAL ENVIRONMENT
NEW DEVELOPMENTS IN COMPUTER-AIDED DETECTION RESEARCH
REFERENCES 2. SEBACEOUS CARCINOMA OF THE BREAST: CLINICOPATHOLOGIC FEATURES INTRODUCTION
METHODS
CLINICAL FEATURES
PATHOLOGIC FINDINGS
DIFFERENTIAL DIAGNOSIS
PROGNOSIS AND TREATMENT
REFRENCES 3. BREAST CANCER: DETECTION BY IN VIVO IMAGING OF ANGIOGENESIS Tore Bach-Gansmo and Derek Tobin INTRODUCTION
ANGIOGENESIS
INTEGRINS
SCINTIMAMMOGRAPHY
TECHNETIUM-LABELED NC100692
INITIAL CLINICAL EXPERIENCE
99mTc-NC100692 IN BREAST CANCER
IMPROVEMENTS IN GAMMA CAMERA TECHNOLOGY
SUPPLEMENTARY CLINICAL STUDY
FUTURE INTEGRIN SCINTIGRAPHY
REFERENCES 4. BREAST AND PROSTATE BIOPSIES: USE OF OPTIMIZED HIGH-THROUGHPUT MicroRNA EXPRESSION FOR DIAGNOSIS (METHODOLOGY) Michael D. Mattie and Robert C. Getts INTRODUCTION
METHODOLOGY FOR HIGH-THROUGHPUT microRNA PROFILING
Purification of microRNA
AMPLIFICATION OF LOW MOLECULAR WEIGHT RNA
LABELING OF microRNA
REFERENCES 5. FAMILIAL BREAST CANCER: DETECTION OF PREVALENT HIGH-RISK EPITHELIAL LESIONS Peter Bult and Nicoline Hoogerbrugge INTRODUCTION
MATERIALS
METHODS
CLASSIFICATION OF PREMALIGNANT LESIONS
REFERENCES 6. DIFFERENTIATION BETWEEN BENIGN AND MALIGNANT PAPILLARY LESIONS OF THE BREAST: EXCISIONAL BIOPSY OR STEREOTACTIC VACUUM-ASSISTED BIOPSY (METHODOLOGY) Alice P.Y. Tang, Gary M.K. Tse, and Wynnie W.M. Lam INTRODUCTION
RADIOLOGICAL APPEARANCE OF PAPPILARY LESIONS OF THE BREAST
PATHOLOGICAL FINDINGS
ASSOCIATION OF PAPPILARY LESIONS WITH DUCTAL CARCINOMA
FINE NEEDLE ASPIRATION
CORE NEEDLE BIOPSY
CURRENT ROLE OF EXCISIONAL BIOPSY
DIFFICULTY IN PATHOLOGICAL DIFFERENTIATION BETWEEN MALIGNANT AND BENIGN LESIONS AFTER NEEDLE BIOPSY
VACCUM-ASSISTED BIOPSY
TECHNIQUE OF STEREOTACTIC VACCUM-ASSISTED BIOPSY
TECHNIQUE OF ULTRASOUND-GUIDED VACCUM-ASSISTED BIOPSY
ADVANTAGES OF DIRECTIONAL VACCUM-ASSISTED DEVICE
COMPLICATIONS OF VACCUM ASSISTED BIOPSY
CURRENT EXPERIENCE OF VACCUM-ASSISTED BIOPSY AND PERCUTANEOUS CORE BIOPSY IN THE MANAGEMENT OF PAPPILARY LESIONS
IS EXCISION BIOPSY NEEDED IN ASSESSING PAPPILARY LESIONS OF THE BREAST
ATYPICAL PAPILLOMA/ PAPILLARY LESION WITH ATYPICAL DUCTAL HYPERPLASIA AT VACCUM-ASSISTED BIOPSY
BENIGN PAPILLOMA AT VACCUM-ASSISTED BIOPSY
REFERENCES 7. MULTICENTRIC BREAST CANCER: SENTINEL NODE BIOPSY AS A DIAGNOSTIC TOOL Michael Knauer, Peter Konstantiniuk, Anton Haid, Etienne Wenzl, Roswitha Koeberle-Wuhrer, Michaela Riegler-Keil, Sabine Poestlberger, Roland Reitsamer, and Peter Schrenk INTRODUCTION
TECHNIQUE OF SENTINEL NODE BIOPSY IN MULTICENTRIC BREAST CANCER
Technique of Lymphatic Mapping
Histologic Evaluation of Sentinel Nodes
Surgical Procedures
RESULTS OF THE AUSTRIAN SENTINEL NODE STUDY GROUP
Patients and Data
Follow-up
DISCUSSION
Clinical Advantage of Sentinel Node Biopsy in Multicentric Breast Cancer
Quality Control of Sentinel Node Biopsy Procedure
REFERENCES 8. BREAST CANCER RECURRENCE: ROLE OF SERUM TUMOR MARKERS CEA AND CA 15-3 (METHODOLOGY) Franco Lumachi, Stefano M.M. Basso, and Umberto Basso INTRODUCTION
SERUM TUMOR MARKERS AND BREAST CANCER
CARCINOEMBRYONIC ANTIGEN
CANCER ANTIGEN 15-3
PREDICTION OF RISK OF RECURRENCE AND LOCOREGIONAL RELAPSE
MONITORING THE RESPONSE TO THERAPY OF