Main description:

Molecular Pathology of Neoplastic Gastrointestinal Diseases reviews the molecular aspects that characterize the spectrum of neoplastic conditions that affect the gastrointestinal tract, providing the reader with current up-to-date knowledge. For each disease entity chapters provide reviews on:

the molecular basis of the individual disease
molecular testing approaches currently available or in development for diagnosis or for gene target characterization for selective targeted therapies
recommended guidelines for clinical application of molecular tests are included whenever available
molecular testing for hereditary predisposition or disease risk
animal models and cell culture models of disease

Contents:

Section 1. Introduction

1. Mechanisms of Gastrointestinal Carcinogenesis

By Frank I. Scott and John P. Lynch

Section 2. Epithelial Neoplastic Disease

2. Targeted Therapies and Molecular Diagnostics of Gastrointestinal Cancers

By Davendra Sohal, Antonia R. Sepulveda, and Weijing Sun

3. Molecular Pathology of Barrett's Metaplasia and Esophageal Adenocarcinoma

By Mamoun Younes

4. Molecular Pathology of Squamous Carcinomas of the Esophagus

By Rohinton S. Tarapore and Jonathan P. Katz

5. Molecular Mechanisms and Pathology of Gastric Carcinogenesis: Sporadic Cancers

By Shuko Harada and Antonia R. Sepulveda

6. Hereditary Diffuse Gastric Cancer and Other Gastric Cancers Associated with Hereditary Predisposition Syndromes

By Fatima Carniero, Carla Oliveira, and Raquel Seruca

7. Cancer Predisposition Syndromes of the Gastrointestinal Tract

By Ian S. Hagemann and Antonia R. Sepulveda

8. Molecular Pathology of Colon and Small Bowel Cancers: Sporadic Types

By Asif Rashid

9. Cancers of the Rectum and Anal Canal

By Jenia Jenab-Wolcott and Bruce Giantonio

10. Molecular Pathology of Inflammatory Bowel Disease Associated Neoplasia

By Takeshi Uehara, Deqin Ma, and Antonia R. Sepulveda

Section 3. Non-Epithelial Neoplastic Tumors

11. Molecular Biology and Pathology of Gastrointestinal Stromal Tumors

By Paul J Zhang

12. Neuroendocrine Tumors

By Joseph R Pisegna

Section 4. Metastatic Disease and Tumor Markers

13. Molecular Mechanisms of Tumor Metastases

By Andrew Rhim, Davendra Sohal, and Hiroshi Nakagawa

14. Circulating Tumor Cells and Nucleic Acids for Tumor Diagnosis

By Loren Joseph

15. Serological Markers of Digestive Tract Cancers

By Jorge L Sepulveda

By Andrew Rhim, Davendra Sohal, and Hiroshi Nakagawa

14. Circulating Tumor Cells and Nucleic Acids for Tumor Diagnosis

By Loren Joseph

15. Serological Markers of Digestive Tract Cancers

By Jorge L Sepulveda