Main description:

This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2.

Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.

Contents:

Chapter 1
Molecular basis of breast cancer imaging
Gopal R. Vijayaraghavan, Srinivasan Vedantham , Ashraf Khan, Andrew Karellas

Chapter 2
Familial Breast Cancer and Genetic Predisposition in Breast Cancer
Vighnesh Walavalkar, Ashraf Khan, Dina Kandil

Chapter 3
Modelling the Molecular Pathology of Breast Cancer Initiation
Claire Nash, Andrew M. Hanby, Valerie Speirs

Chapter 4
Molecular Pathology of Precancerous Lesions of the Breast
Abhik Mukherjee, Ian O. Ellis, Emad A. Rakha

Chapter 5
Breast Cancer Stem Cells: Role in Tumor Initiation, Progression and Targeted Therapy
Sanjoy Samanta, Ashraf Khan, Arthur M. Mercurio

Chapter 6
Molecular Pathology of Pre-Invasive Ductal Carcinoma
Yuna Gong, Dina Kandil, Ashraf Khan

Chapter 7
Molecular Pathology of Lobular Carcinoma
Ali Sakhdari, Lloyd Hutchinson, Ediz Cosar

Chapter 8
Molecular Pathology of Hormone Regulation in Breast Cancer: Hormone Receptor Evaluation and Therapeutic Implications
Emad A Rakha

Chapter 9
Molecular Pathology of HER Family of Oncogenes in Breast Cancer: HER-2 Evaluation and Role in Targeted Therapy
Lloyd Hutchinson, Ali Sakhdari, Ediz Cosar

Chapter 10
Molecular Classification of Breast Cancer
Mohammed Aleskandarany, Ian O. Ellis, Emad A. Rakha

Chapter 11
Triple Negative Breast Cancer: Subtypes with Clinical Implications
Dina Kandil, Ashraf Khan

Chapter 12
Molecular-based Diagnostic, Prognostic and Predictive Tests in Breast Cancer
Abir A. Muftah, Mohammed Aleskandarany, Ian O. Ellis, Emad A Rakha

Chapter 13
Role of MicroRNAs in Breast Cancer
Jennifer M. Clarke, Dina Kandil, Ediz Cosar, Ashraf Khan

Chapter 14
Molecular Pathology of Fibroepithelial Neoplasms of the Breast
Michelle Yang, Dina Kandil, Ashraf Khan

Chapter 15
Molecular Features of Mesenchymal Tumors of the

Breast
Marjan Mirzabeigi, Ashraf Khan, Dina Kandil

Chapter 16
Molecular Pathology of Breast Cancer Metastasis
Mohammed Aleskandarany, Ian O. Ellis, Emad A. Rakha

Chapter 17
The molecular pathology of chemoresistance during the therapeutic response in breast cancer
James L Thorne, Andrew M. Hanby, Thomas A. Hughes

Chapter 18
The Molecular Pathology of Male Breast Cancer
Rebecca A Millican-Slater, Valerie Speirs, Thomas A. Hughes, Andrew M. Hanby

Chapter 19
Specimens for Molecular Testing in Breast Cancer
Ali Sakhdari, Lloyd Hutchinson, Ediz Cosar