Main description:

This volume thoroughly describes the fundamentals of a new multidisciplinary field of study that aims to deepen our understanding of the human body by combining medical image processing, mathematical analysis, and artificial intelligence. Multidisciplinary Computational Anatomy (MCA) offers an advanced diagnosis and therapeutic navigation system to help detect or predict human health problems from the micro-level to macro-level using a four-dimensional, dynamic approach to human anatomy: space, time, function, and pathology. Applying this dynamic and "living" approach in the clinical setting will promote better planning for - and more accurate, effective, and safe implementation of - medical management.
Multidisciplinary Computational Anatomy will appeal not only to clinicians but also to a wide readership in various scientific fields such as basic science, engineering, image processing, and biomedical engineering. All chapters were written by respected specialists and feature abundant color illustrations. Moreover, the findings presented here share new insights into unresolved issues in the diagnosis and treatment of disease, and into the healthy human body.

Contents:

1 Introduction
I: Perspectives of MCA 2 MCA: cancer detection, surgical and interventional sciences 3 AI & Healthcare: Towards a digital twin? 4 Perspectives of MCA
II: Fundamental Theories and Techniques 5 Principle of MCA 6 Mathematical foundations of MCA 7 Fundamental technologies for integration of multiscale spatiotemporal morphology in MCA 8 Fundamental technology for integration of function and pathology in MCA
III: Application Systems and Applied techniques based on MCA model 9 Pre/intra-operative diagnosis and navigational assistance based on MCA 10 Cancer diagnosis and prognosis assistance based on MCA 11 Function integrated diagnostic assistance based on MCA models
IV: Clinical and scientific Application of MCA 12 Clinical applications of MCA to surgery 13 Clinical applications of MCA to diagnosis 14 Application of MCA across biomedical engineering
V: New frontier in fundamentals on MCA models 15 Multi-modal and multi-scale image registration for property analysis of brain tumor 16 Quantitative evaluation of diseased tissue by viscoelastic imaging systems 17 Development of a generation method for local appearance models of normal organs by DCNN 18 Application of structured light illumination and compressed sensing to high speed laminar optical fluorescence tomography 19 MCA analysis for the change in the cardiac fiber orientation at congestive heart failure 20 Development of measurement technique for 3D deformation field of multiphase structure aiming at the elucidation of tumour invasive mechanism 21 Three-dimensional analysis at human organogenesis 22 Construction of classifier of tumore cell types of pancreas cancer based on pathological images using deep learning 23 Analysis on three-dimensional morphologies of hepatic microstructures in hepatic disease 24 Disorder development onset prediction based on spatiotemporal statistical shape model 25 Developmental disorder and risk evaluation by modeling 26 Magnetic resonance Q-space imaging using generating function and Bayesian inference 27 Supermodeling in analysis for multidisciplinary medical data
VI: New frontier of CAD (computer-aided diagnosis) and CAS (computer-aided surgery) systems based on MCA models 28 Brain MRI image analysis technologies and its application to medical image analysis of Alzheimer's diseases 29 A machine learning based framework for developing various computer-assisted detection system with generated image features 30 Computerized evaluation of pulmonary function based on the rib and diaphragm motion by dynamic chest radiography 31 Creation of large-scale and high-performance technology for processes of MCA by utilizing supercomputers 32 Ultrahigh resolution optical coherence microscopy at visible to near-infrared wavelength region 33 Magneto-stimulation system for brain based on medical images 34 Analysis of central nervous system and skeletal system during human early-fetal period based on MCA 35 Quantitative evaluation of fatty metamorphosis and fibrosis of liver based on models of ultrasound and light propagation and its application to hepatic disease diagnosis 36 A computer aided support system for deep brain stimulation by multidisciplinary brain atlas database 37 Development of multiple skeletal muscle recognition technique in the thoracoabdominal region for respiratory muscle function analysis 38 Application study on micro-tomographic visualization of spatio-temporal mechanical characteristics of regenerated tissue 39 Integrate of bio-metabolism and structural change for diagnosis of dementia
VII: New Frontier of clinical and scientific applications of MCA models40 Education of Embryology by human fetus 41 MicroCT and histological diagnosis 42 MCA analysis for hepatology 43 Development of general biophysical model for realization of ultrasonic qualitative real-time pathological diagnosis 44 Autonomous control of a surgical assistant robot with a stereoscopic endoscope that can obtain depth information in real time 45 Computer-aided diagnosis of interstitial lung disease on ultra-high-resolution CT imaging parallel to the chest wall with artificial intelligence 46 Morphometric analysis for the morphogenesis of the craniofacial structures and the evolution of the nasal protrusion in humans 47 Postoperative prediction of pulmonary resection based on MCA model by integrating the temporal responses and biomechanical functions 48 Development of bone strength prediction method by using MCA with damage mechanics 49 Computer-aided diagnostic system based on deep learning which supports endoscopists' decision making on the treatment of colorectal polyps 50 Modeling for congenital heart malformation focused on topology 51 Normalized brain datasets with functional information project the future- predicting glioma surgery 52 Artificial intelligence based radiogenomic diagnosis of gliomas 53 Similation surgery for Hepatobiriary pancreatic surgery 54 Application of MCA modeling to abnormal nerve plexus in the GI tract 55 Fusion of AR and IoT at the operation room 56 Strategy for Future OR 57 Four-dimensional dynamic images: principle and future application