Main description:

Polymeric Drug Delivery: Science & Application is designed to bridge the gap between industrial and academic researchers in drug delivery and the pharmaceutical industry because conferences focus one of these two aspects. The book covers three main topics of drug delivery: the use of particulate carriers to transport actives to specific sites within the body, the use of matrices to tailor release rates to drug specific needs, and technologies to engineer
drug particles in a way that will improve their bioavailability. Polymeric materials are being used in all three areas, as carriers, matrices, or part of the formulation of drug particles. Following an overview, this volume describes in twenty chapters the use of carriers such as liposomes, micelles, dendrimers,
emulsion droplets, nanoparticles, and yeast cells in the (targeted) delivery of poorly water-soluble drugs, small organic molecules, macromolecules such as proteins and nucleic acids, and metal ions for molecular imaging purposes. Different routes of application are described, including oral and transepithelial delivery.

Contents:

Preface
Overview
1: Sonke Svenson: Advances in Particulate Polymeric Drug Delivery
Particulate Drug Carriers
2: Ronak Vakil, Anuj Kuldipkumar, David Andes, Yvonne Tan and Glen S. Kwon: Polymeric Micelles for the Delivery of Polyene Antibiotics
3: Masayuki Yokoyama: Polymeric Micelle Drug Carriers for Tumor Targeting
4: Cornelus F. van Nostrum, Dragana Neradovic, Osamu Soga, and Wim E. Hennink: Polymeric Micelles with Transient Stability: A Novel Drug Delivery Concept
5: Mira F. Francis, Mariella Piredda, Mariana Cristea and Francoise M. Winnik: Synthesis and Evaluation of Hydrophobically-Modified Polysaccharides as Oral Delivery Vehicles for Poorly-Water Soluble Drugs
6: Pingwah Tang, NaiFang Wang and Steven M. Dinh: Oral Delivery of Macromolecular Drugs
7: Jan A.A.M. Kamps, Henriette W.M. Morselt, Gerrit L. Scherphof and Gerben A. Koning: Immunoliposomes Directed Against Colon Adenocarcinoma Cells: Delivery of 5-Fluorodeoxyuridine to Colon Cancer Cells and Targeting to Liver Metastases
8: Debra T. Auguste, Robert K. Prud'homme, Patrick L. Ahl, Paul Meers and Joachim Kohn: Polymer-Protected Liposomes: Association of Hydrophobically-Modified PEG with Liposomes
9: Eric E. Simanek: Dendrimers Based on Melamine: Vehicles for Drug Delivery?
10: K. Bruce Thurmond II, John McEwan, Dan G. Moro, John R. Rice, Gregory Russell-Jones, John V. St. John, Paul Sood, Donald R. Stewart and David P. Nowotnik: Targeted and Non-Targeted Polymer Drug Delivery Systems
11: M. C. Morris, J. Depollier, S. Deshayes, F. Heitz and G. Divita: Peptide Carriers for Protein Transduction: How to Generate a Drug from your Favorite Protein
12: Jonathan B. Rothbard, Theodore C. Jessop, Paul A. Wender: Molecular Understanding of Cellular Uptake by Arginine-Rich Cell Penetrating Peptides
13: Darin Y. Furgeson and Sung Wan Kim: Recent Advances in Poly(ethyleneimine) Gene Carrier Design
14: Preeti Yadava, David Buethe and Jeffery A. Hughes: Nonviral Gene Delivery with Surfactants
15. Gene Delivery with Novel Poly(L-tartaramidoamine)s
Yemin Liu, Laura Wenning, Matthew Lynch and Theresa M. Reineke
16: Edmund J. Niedzinski, Yadong Liu, and Eric Y. Sheu: Plasmid DNA Encapsulation Using an Improved Double Emulsion Process
17: Yoon Yeo and Kinam Park: A New Microencapsulation Technique Based on the Solvent Exchange Method
18: Kurt Breitenkamp, Denise Junge and Todd Emrick: Hollow Microcapsules for Drug Delivery by Self-Assembly and Crosslinking of Amphiphilic Graft Copolymers
19: G. Nelson, S.C. Duckham and M.E.D. Crothers: Microencapsulation in Yeast Cells and Applications in Drug Delivery
20: R. Keith Frank, Philip S. Athey, Gyongyi Gulyas, Garry E. Kiefer, Kenneth McMillan and Jaime Simon: Chelants for Delivery of Metal Ions
21: G. M. Lanza, P. M. Winter, M. S. Hughes, S. D. Caruthers, J. N. Marsh, A. M. Morawski, A. H. Schmieder, M. J. Scott, R. W. Fuhrhop, H. Zhang, G. Hu, E. K. Lacy, J. S. Allen and S. A. Wickline: Molecular Imaging and Therapy - New Paradigms for 21st Century Medicine