Main description:

Over the past decade, diagnostics and therapeutics research has evolved towards the use of more specific and targeted approaches. A most profound impact has been observed in the nanotechnology sectors, where an explosion in directing molecules to specific biomarkers has illustrated great potential not only in detection but also in targeted therapy. As some of the most common cell-surface ligands, carbohydrates and glyco-conjugates are known to play crucial roles in
many medicinally important physiological processes, including inflammatory and immunological responses, tumor metastasis, cell-cell signaling, apoptosis, cell adhesion, bacterial and viral recognition, and anticoagulation. Glyco-nanotechnology, the interfacing of glycoscience and nanotechnology, is an
exciting new field to translate basic discoveries into important clinical applications.

This book describes current progress in the glyco-nanotechnology field. It will provide the readers with knowledge of the current status of glyco-nanotechnology research and kindle additional interests in this field. There are tremendous opportunities in biomedical applications of glyconanomaterials and we have just begun to uncover them.

Contents:

Preface ; 1. Recent Biotechnological Applications of Glyco-Nanomaterials ; Sung You Hong, Malcolm L. H. Green, and Benjamin G. Davis ; 2. Functionalized Glyconanoparticles for the Study of Glycobiology ; Wei-Ting Chien, Ching-Ching Yu, Chien-Fu Liang, Chian-Hui Lai, Po-Chiao Lin, and Chun-Cheng Lin ; 3. Chemoselectivity and Glyconanoparticles ; Mikkel B. Thygesen and Knud J. Jensen ; 4. Synthesis of Glyconanomaterials via Photo-Initiated Coupling Chemistry ; Xin Wang, Oscar Norberg, Lingquan Deng, Olof Ramstrom, and Mingdi Yan ; 5. Strategies for the Characterization of the Saccharidic Moiety in Composite Nanoparticles ; Carlo Morasso, Paolo Verderio, Miriam Colombo, and Davide Prosperi ; 6. Enhanced Inhibition of Protein Carbohydrate Interactions by Dendritic Multivalent Glycoligands ; Roland J. Pieters ; 7. Glyco-Functionalized Quantum Dots ; Jacob J. Weingart and Xue-Long Sun ; 8. Sugar-Functionalized Carbon Nanotubes: Unique Properties and Interactions with Biological Species ; Parambath Anilkumar, Kenneth N. Tackett II, Fushen Lu, Pengju G. Luo, Lingrong Gu, Ankoma Anderson, and Ya-Ping Sun ; 9. Synthetic Glycans, Glycoarrays, and Glyconanoparticles To Investigate Host Infection by Trypanosoma cruzi ; Robert A. Field, Peterson Andrade, Vanessa L. Campo, Ivone Carvalho, Beatrice Y. M. Collet, Paul R. Crocker, Margherita Fais, Rositsa Karamanska, Balaram Mukhopadhayay, Sergey A. Nepogodiev, Abdul Rashid, Martin Rejzek, David A. Russell, Claire L. Schofield, and Renate M. van Well ; 10. Glyco-Nanoparticles as Platforms for Antitumor Therapeutic Strategies ; Joseph J. Barchi, Jr. ; 11. Biological Applications of Hyaluronic Acid Functionalized Nanomaterials ; Mohammad El-Dakdouki and Xuefei Huang ; Editors' Biographies ; Indexes ; Author Index ; Subject Index