Main description:

This fully-updated book provides systems-based methodologies and innovative technologies that can be used for solving complicated problems of complex systems. A wide range of theoretical and experimental approaches are introduced for practical applications, as the content explores the basic and novel concepts in psychoneuroimmunology (PNI), especially the relationships among stress, inflammation, and psychophysiological disorders, as well as various cutting-edge technologies and methods for PNI studies, including the utilizations of mouse models and vaccine models. In addition, this book focuses on translational medicine by applying PNI methods in clinical practice. As part of the Methods in Molecular Biology series, the chapters seek to provide a practical, state-of-the-art, and holistic view for the translation of PNI into better preventive and personalized medical practice.
Authoritative and hands-on, Psychoneuroimmunology: Methods and Protocols, Second Edition will be of use to biomedical students and professionals at all levels who are interested in integrative studies in psychology, psychiatry, neuroscience, immunology, molecular biology, genetics, bioengineering, physiology, pathology, microbiology, systems biology, and clinical medicine.

Contents:

Part I: Stress and Immunity: Biopsychosocial Models and Clinical Implications

1. Stress and Systemic Inflammation: Yin-Yang Dynamics in Health and Diseases

Qing Yan

2. Intersections between Neuroimmune-Microbiota

Colette G. Ngo Ndjom, Xavier F. Gonzalez, and Harlan P. Jones

3. Psychoneuroimmunology: The Experiential Dimension

Elling Ulvestad

4. Ecological Context and Human Variation: Applying the Principles of Biological Anthropology to Psychoneuroimmunology

Eric C. Shattuck

5. Neuroimmune Imbalances and Yin-Yang Dynamics in Stress, Anxiety, and Depression

Qing Yan

6. Increasing Resilience to Traumatic Stress: Understanding the Protective Role of Well-Being

J. Tory Toole, Mark A. Rice, Jr., Jordan Cargill, Travis J.A. Craddock, Barry Nierenberg, Nancy G. Klimas, Mary Ann Fletcher, Mariana Morris, Joel Zysman, and Gordon Broderick

7. Exploring the Diagnostic Potential of Immune Biomarker Co-Expression in Gulf War Illness

Gordon Broderick, Mary Ann Fletcher, Michael Gallagher, Zachary Barnes, Suzanne D. Vernon, and Nancy Klimas

8. Breaking Away: The Role of Homeostatic Drive in Perpetuating Depression

J. Tory Toole, Mark A. Rice, Jr., Travis J.A. Craddock, Barry Nierenberg, Nancy G. Klimas, Mary Ann Fletcher, Joel Zysman, Mariana Morris, and Gordon Broderick

9. Neuroimmune Mechanisms of Depression in Adults with Heart Failure

Jessica A. Jimenez, Christine Tara Peterson, and Paul J. Mills

10. How To Monitor the Neuroimmune Biological Response in Patients Affected by Immune Alteration-Related Systemic Diseases

Paolo Lissoni, Franco Rovelli, Luigi Vigore, Giusy Messina, Arianna Lissoni, Giorgio Porro, and Giuseppe Di Fede

Part II: Technologies and Methods in Psychoneuroimmunology Studies

11. Application of Chemogenetics and Optogenetics to Dissect Brain-Immune Interactions

Ben Korin and Asya Rolls

12. Psychoneuroimmunology and Natural Killer Cells: The Chromium Release Whole Blood Assay

Mary Ann Fletcher, Zachary Barnes, Gordon Broderick, and Nancy G. Klimas

13. Mouse Testing Methods in Psychoneuroimmunology 2.0: Measuring Behavioral Responses

Albert E. Towers, Jason M. York, Tracy Baynard, Stephen J. Gainey, and Gregory G. Freund

14. The MRL Model: A Valuable Tool in Studies of Autoimmunity-Brain Interactions

Boris Sakic

15. PET Imaging in Psychoneuroimmunology Research

Jonas Hannestad

16. The Vaccination Model in Psychoneuroimmunology Research: A Review

Anna C. Whittaker

17. Measuring Vaccine Responses in the Multiplex Era

Kieran Ayling, Kavita Vedhara, and Lucy Fairclough

18. Sculpting the Sculptors: Methods for Studying the Fetal Cholinergic Signaling on Systems and Cellular Scales

Martin G. Frasch, Patrick Burns, Javier Benito, Marina Cortes, Mingju Cao, Gilles Fecteau, and Andre Desrochers

19. Perinatal Psychoneuroimmunology: Protocols for the Study of Prenatal Stress and Its Effects on Fetal and Postnatal Brain Development

Martin G. Frasch, Carlos J. Baier, Marta C. Antonelli, and Gerlinde A.S. Metz