Main description:

Stem Cell Biology in Health and Disease presents an up-to-date overview about the dual role of stem cells in health and disease. The Editors have drawn together an international team of experts providing chapters which, in this fully-illustrated volume, discuss:

- the controversial debate on the great expectations concerning stem cell based regeneration therapies raised by the pluripotency of various stem cells.
- the advantages and concerns about embryonic stem cells (ES cells), induced pluripotent stem cells (iPS cells) and adult stem cells, such as bone marrow-derived stem cells (BMDCs).
- the type of stem cells, which has become of interest in the past decade, namely so-called cancer stem cells (CSCs). CSCs are now in the focus of cancer research since the eradication of tumour initiating cells would raise the changes of definitely cure cancer.

Professor Dittmar and Professor Zanker have edited a must-read book for researchers and professionals working in the field of regenerative medicine and/or cancer.

Contents:

1) Introduction; T. Dittmar, K.S. Zanker

Bone marrow-derived stem cells

2) Hematopoietic stem and progenitor cells in clinical use - transplantation and mobilization; M. Punzel

3) Ex-vivo Expansion of HSPCs; Y. Wei

4) Modulation of hematopoietic stem/progenitor migration; T. Dittmar

5) Properties of mesenchymal stem cells to consider for cancer cell therapy; J. Stagg

Embryonic stem cells

6) Alternative embryonic stem cell sources; T. Saric, J. Hescheler
7) Cell therapy in Parkinson's Disease; R. Laguna Goya, R. A. Barker

8) Transplantation of stem cells and their derivatives in the treatment of multiple sclerosis; E. Larsen, I. Duncan
Cancer Stem Cells

9) Cancer - A Stem Cell-based disease?; J. E. Trosko

10) Stem Cell Niche vs. Cancer Stem Cell Niche - Differences and Similarities; B. C. Baguley, G. J. Finlay

11) The chronically inflamed microenvironment and cancer stem cells; H. Li, C. Stoicov, X. Fan, J. Cerny, J.M. Houghton

12) Does the chronically inflamed periodontium harbour cancer stem cells?; W.-D. Grimm, W. H. Arnold, S. Becher, A. Dannan, G. Gassmann, S. Philippou, T. Dittmar, G. Varga

13) Cancer Stem Cells in the Haematopoietic System/ Haematopoietic Stem/ Progenitor Cell Disorders; M. Muschen

14) Cancer stem cells in solid tumors; M. G. Nafus, A. Y.Nikitin

15) 'One for all' or 'All for one'? - The necessity of cancer stem cell diversity in metastasis formation and cancer relapse; T. Dittmar, C. Nagler, S. Schwitalla, K. Krause, J. Seidel, G. Reith, B. Niggemann, K. S. Zanker

16) Elimination of Cancer Stem Cells; A. Sagrera, J. Perez-Losada, M. Perez-Caro, R. Jimenez, I. Sanchez-Garcia, C. Cobaleda

17) Potential molecular therapeutic targets in cancer stem/progenitor cells: Are ATP-binding cassette membrane transporters appropriate targets to eliminate cancer-initiating cells?; M. Mimeault, S. K. Batra