Completely updated, the Fifth Edition of this standard-setting two-volume reference presents the most advanced diagnostic techniques and the latest information on all currently known disease entities. More than 90 preeminent surgical pathologists offer expert advice on the diagnostic evaluation of every type of specimen from every anatomic site. The Fifth Edition contains over 4,400 full-color photographs.

This edition provides detailed coverage of the latest developments in the field, including new molecular and immunohistochemical markers for diagnosis and prognosis of neoplasia, improved classification systems for diagnosis and prognosis, the role of pathology in new diagnostic and therapeutic techniques, and the recognition of new entities or variants of entities. Where appropriate updated World Health Organization (WHO) terminology has been employed for tumor diagnosis. A few of the many specific changes include:

• An update on the serrated adenoma and serrated carcinoma pathway
• Virtually new chapters on salivary gland, larynx, blood vessels, heart, non-melanocytic skin tumors, and placenta
• Complete updates of the lymph node and bone marrow chapters incorporating the new WHO terminology
• An expanded discussion of the molecular biology of thyroid neoplasia

All full-color illustrations have been color-balanced to dramatically improve image quality.

A companion Website will include the fully searchable text and an image bank.

SKIN, SOFT TISSUE, BONE & JOINTS: Nonneoplastic Diseases of the Skin, D.C. Parker, R.J. Morris & A.R. Solomon / Non-Melanocytic Cutaneous Tumors, J.W. Patterson / Melanocytic Lesions, A. Piris, N. Prieto-Granada, M.J. Imber & M.C. Mihm, Jr. / Muscle Biopsy in Neuromuscular Diseases, R.R. Heffner, Jr. & L.L. Balos / Disorders of Soft Tissue, J.S.J. Brooks / Joint Diseases, P.G. Bullough / Nonneoplastic Diseases of Bones, P.G. Bullough / Bone Tumors, C.Y. Inwards & K.K. Unni

BREAST: The Breast, D. Carter, S.J. Schnitt, R.R. Millis & H.A. Oberman

CENTRAL NERVOUS SYSTEM: The Brain, Spinal Cord & Meninges, P.E. McKeever

ENDOCRINE SYSTEM: The Neuroendocrine & Paracrine Systems, R.V. Lloyd & L.A. Erickson / The Pituitary & Sellar Region, B.W. Scheithauer / Pathology of Thyroid & Parathyroid Disease, Z.W. Baloch & V.A. LiVolsi / The Adrenal Glands, R.A. DeLellis & S. Mangray / Paragangliomas, E.E. Lack & J.A. Wieneke

HEMATOPOIETIC & LYMPHATIC SYSTEMS: Disorders of Bone Marrow, R.W. McKenna & S.H. Kroft / Lymph Nodes, J.B. Cousar, W.R. Macon, T.L. McCurley & S.H. Swerdlow / The Spleen, J.S. Burke

HEAD & NECK: The Jaws & Oral Cavity, R.J. Zarbo / Salivary Glands, S.E. Mills / The Nose, Paranasal Sinuses & Nasopharynx, S.E. Mills / The Larynx, E.B. Stelow / The Ear & Temporal Bone, B.M. Wenig / The Eye & Ocular Adnexa, G.K. Klintworth & T.J. Cummings

INTRATHORACIC ORGANS & BLOOD VESSELS: Nonneoplastic Pulmonary Disease, A.S. Patchefsky / Pulmonary Neoplasms, M. Noguchi & Y. Shimosato / The Pleura, H. Battifora / The Mediastinum, M.R. Wick / The Heart, G.J. Berry & C.C. Marboe / Blood Vessels, A. Burke & R. Virmani

ALIMENTARY CANAL & ASSOCIATED ORGANS: Esophagus, L.M. Yerian & J.R. Goldblum / The Stomach, D.A. Owen / Nonneoplastic Intestinal Diseases, R.E. Petras & T.L. Gramlich / Intestinal Neoplasms, H.S. Cooper / Pancreas, L.D.R. Thompson & C.S. Heffess / Non-Neoplastic Liver Disease, D.C. Snover / Masses of the Liver, K. Washington & E. Harris / Gallbladder, Extrahepatic Biliary Tree & Ampulla, N.V. Adsay / Anus & Perianal Area, H.D. Appelman

URINARY TRACT & MALE GENITAL SYSTEM: Developmental Abnormalities of the Kidney, E. Gilbert-Barness & P. Khanna / Adult Renal Diseases, T. Nádasdy, A. Satoskar & F.G. Silva / Adult Renal Tumors, V.E. Reuter & S.K. Tickoo / Renal Neoplasms of Childhood, P. Argani & J.B. Beckwith / The Urothelial Tract: Renal Pelvis, Ureter, Urinary Bladder & Urethra, V.E. Reuter / The Prostate & Seminal Vesicles, J.I. Epstein / Nonneoplastic Diseases of the Testis, H.S. Levin & L.R. Schoenfield / Testicular & Paratesticular Tumors, T.M. Ulbright and D.M. Berney / The Penis, E.F. Velazquez, J.E. Barreto, G. Ayala & A.L. Cubilla

FEMALE REPRODUCTIVE SYSTEM & PERITONEUM: Gestational Trophoblastic Disease, I.-M. Shih, M.T. Mazur & R.J. Kurman / The Placenta, C.G. Kaplan & G.P. Altshuler / The Vulva & Vagina, M.H. Stoler & S.E. Mills / The Cervix, M.R. Nucci & C.P. Crum / The Uterine Corpus, T.A. Longacre, K.A. Atkins, R.L. Kempson & M.R. Hendrickson / Ovarian Surface Epithelial Stromal Tumors, P.B. Clement & R.H. Young / Sex Cord—Stromal, Steroid Cell & Germ Cell Tumors of the Ovary, R.H. Young & P.B. Clement / Miscellaneous Primary Tumors, Secondary Tumors & Non-Neoplastic Lesions of the Ovary, R.H. Young & P.B. Clement / The Fallopian Tube & Broad Ligament, R.H. Young & P.B. Clement / The Peritoneum, P.B. Clement & R.H. Young