Main description:

The field of stroke and cerebrovascular disease in children is one in which there has been much recent research activity leading to new clinical perspectives. This book, for the first time, summarises the ′state of the art′ in this field. A team of eminent clinicians, neurologists and researchers from Britain, Europe and Canada provide an up–to–the–minute account of all aspects of stroke and cerebrovascular disease in children, ranging from a historical perspective to future directions, through epidemiology, the latest neuroimaging techniques, neurodevelopment, co–morbidities, diagnosis and treatment. The authors′ practical approach to the clinical problems makes this essential reading for practising clinicians. It will also be of interest to researchers in the field.

Back cover:

The field of stroke and cerebrovascular disease in children is one in which there has been much recent research activity leading to new clinical perspectives. This book, for the first time, summarises the ′state of the art′ in this field. A team of eminent clinicians, neurologists and researchers from Britain, Europe and Canada provide an up–to–the–minute account of all aspects of stroke and cerebrovascular disease in children, ranging from a historical perspective to future directions, through epidemiology, the latest neuroimaging techniques, neurodevelopment, co–morbidities, diagnosis and treatment. The authors′ practical approach to the clinical problems makes this essential reading for practising clinicians. It will also be of interest to researchers in the field.

Contents:

AUTHORS′ APPOINTMENTS ix

1. CHILDHOOD STROKE THE UNKINDEST CUT OF ALL: A HISTORY OF CEREBROVASCULAR DISEASE IN CHILDHOOD 1
Andrew N. Williams and Fenella J. Kirkham

2. DEVELOPMENT OF THE BRAIN CIRCULATION 17
Chao Bao Luo, Marina Sachet Ferreira, Hortensia Alvarez, Georges Rodesch and Pierre L. Lasjaunias

3. THE EPIDEMIOLOGY OF CHILDHOOD STROKE 22
Gabrielle deVeber

4. CLINICAL AND IMAGING FEATURES OF CHILDHOOD STROKE 27

4.1 CLINICAL SYNDROMES 27

4.1.1 ANTERIOR CIRCULATION STROKE 27
Fenella J. Kirkham

4.1.2 POSTERIOR CIRCULATION STROKES IN CHILDREN 38
Bhuwan P. Garg

4.1.3 SPINAL CORD STROKE 43
Bettina Harms, Jason MacDonald and Fenella J. Kirkham

4.2 NEUROIMAGING 48

4.2.1 IMAGING OF PAEDIATRIC STROKE 48
Dawn E. Saunders and W.K. Kling Chong

4.2.2 RECENT ADVANCES IN MAGNETIC RESONANCE IMAGING 57
Fernando Calamante, Jacques–Donald Tournier and Alan Connelly

5. RISK FACTORS AND TRIGGERS FOR CRYPTOGENIC (AND SYMPTOMATIC) STROKE 84

5.1 CEREBROVASCULAR DISEASES FROM INFECTIOUS/INFLAMMATORY ORIGIN 84
Guillaume Sébire and Benedict Michel (with a section on human immunodeficiency virus by Nomazulu Dlamini and Fenella J. Kirkham)

5.2 THROMBOPHILIA AND CHILDHOOD STROKE 91
Ulrike Nowak–Göttl and Ronald Sträter

5.3 HYPERTENSION AND CHILDHOOD STROKE 94
Juan C. Kupferman, Fenella J. Kirkham and Steven Pavlakis

5.4 TRAUMA 96
Fenella J. Kirkham

5.5 IRON DEFICIENCY 96
Fenella J. Kirkham

5.6 PATENT FORAMEN OVALE AND PARADOXICAL EMBOLISM 96
Vijeya Ganesan and Fenella J. Kirkham

6. ARTERIAL ISCHAEMIC STROKE AND VASCULAR DISEASE IN CHILDHOOD 107

6.1 CERVICOCEPHALIC ARTERIAL DISSECTIONS IN CHILDHOOD AND ADOLESCENCE 107
Göran Darius Hildebrand and Stéphane Chabrier

6.2 TRANSIENT CEREBRAL ARTERIOPATHY 115
Guillaume Sébire

6.3 MOYAMOYA SYNDROME IN CHILDHOOD 120
Vijeya Ganesan and Brian G.R. Neville

6.4 CEREBRAL VASCULITIS 127
Russell C. Dale

6.5 VASOSPASM 131
Fenella J. Kirkham

6.6 TORTUOSITY AND DOLICHOECTASIA 132
Katharine M.L. Forrest

6.7 DEVELOPMENTAL VENOUS ANOMALIES 133
Mara Prengler and Fenella J. Kirkham

7. CEREBAL SINOVENOUS (VENOUS SINUS) THROMBOSIS 145
Gabrielle deVeber

8. HAEMORRHAGIC STROKE 160

8.1 NON–TRAUMATIC INTRACRANIAL HAEMORRHAGE IN CHILDREN 160
Vijeya Ganesan and Dawn E. Saunders

8.2 SURGICAL TREATMENT OF HAEMORRHAGIC STROKE IN CHILDREN 169
Joan P. Grieve and Neil D. Kitchen

8.3 INTERVENTIONAL NEURORADIOLOGY IN THE MANAGEMENT OF ANEURYSMS AND ARTERIOVENOUS SHUNTS IN CHILDREN 172
Chao Bao Luo, Marina Sachet Ferreira, Hortensia Alvarez, Georges Rodesch, Pierre L. Lasjuanias and Stefan K. Brew

8.4 STEREOTACTIC RADIOSURGERY IN THE MANAGEMENT OF ARTERIOVENOUS MALFORMATIONS IN CHILDREN 177
M.W.R. Radatz and A.A. Kemeny

9. NEONATAL STROKE 183

9.1 PERINATAL ARTERIAL STROKE 183
Frances Cowan and Eugenio Mercuri

9.2 INTRACRANIAL HAEMORRHAGE IN THE NEWBORN 194
Fenella J. Kirkham and Frances Cowan

10. VEIN OF GALEN ANEURYSMAL MALFORMATION 204
Chao Bao Luo, Marina Sachet Ferreira, Hortensia Alvarez, Georges Rodesch, Pierre L. Lasjaunias and Stefan K. Brew

11. STURGE–WEBER SYDROME 212
Sarah Aylett

12. HEMPILEGIC MIGRAINE 217
Sarah Benton, Michel D. Ferrari, Fenella J. Kirkham and Peter J. Goadsby

13. ALTERNATING HEMIPLEGIA OF CHILDHOOD 225
Jean Aicardi and Fenella J. Kirkham

14. INBORN METABOLIC DISEASE AND ACUTE FOCAL NEUROLOGY 233
Robert Surtees and Fenella J. Kirkham

15. SYMPTOMATIC STROKE 245

15.1 CARDIAC DISORDERS 245
Vijeya Ganesen

15.2 GENETICALLY DETERMINED VASCULOPATHIES AND STROKE SYNDROMES WITHOUT NEUROCUTANEOUS STIGMATA 251
Fenella J. Kirkham and Nomazulu Dlamini

15.3 GENETICALLY DETERMINED VASCULOPATHIES AND STROKE SYNDROMES WITH NEUROCUTANEOUS SYNDROMES 256
Fenella J. Kirkham

15.4 CONGENITAL AND ACQUIRED ANAEMIAS 261
Dimitrios Zafeiriou, Mara Prengler, Steven Pavlakis and Fenella J. Kirkham

15.5 IMMUNODEFICIENCY AND BONE MARROW TRANSPLANTATION 287
Fenella J. Kirkham

15.6 PREMATURE AGEING SYDROMES (PROGERIAS) 287
Fenella J. Kirkham

15.7 STROKE IN CHILDREN WITH CANCER 288
Fenella J. Kirkham

15.8 INFLAMMATORY VASCULOPATHIES 293
Fenella J. Kirkham

16. ACUTE MANAGEMENT 319
Rebecca Ichord, Anne Yardumian, Fenella J. Kirkham and Gabrielle DeVeber

17. RECURRENCE, OUTCOME AND REHABILITATION 337

17.1 RECURRENCE AND SECONDARY PREVENTION 337
Vijeya Ganesan and Fenella J. Kirkham

17.2 OUTCOME AFTER STROKE IN CHILDHOOD 340
Anne Gordon, Lucinda Carr, Vijeya Ganesan, Fenella J. Kirkham and Gabrielle deVeber

17.3 ONTOGENETIC SPECIALIZATION OF HEMISPHERIC FUNCTION 354
Faraneh Vargha–Khadem, Elizabeth Isaacs, Kate Watkins and Mortimer Mishkin

17.4 NEURODEVELOPMENTAL OUTCOME IN CHILDREN WITH CONGENITAL HEART DEFECTS 362
Amy Savage, Catherine Hill, Fenella J. Kirkham and Alexandra Hogan

17.5 SICKLE CELL DISEASE: COGNITIVE AND BEHAVIOURAL OUTCOME 370
Alexandra Hogan

17.6 REHABILITATION AFTER STROKE IN CHILDREN 380
Anne Gordon and Lucinda Carr

18. FUTURE DIRECTIONS 398
Vijeya Ganesan and Fenella J. Kirkham

INDEX 403

Colour plates fall between pages 212 and 213.