Main description:

The Geometric Induction of Bone Formation describes new biomimetic biomaterials that offer mechanistic osteogenic surfaces for the autonomous and spontaneous induction of bone formation without the addition of osteogenic soluble molecular signals of the transforming growth factor- supergene family. The chapters frame our understanding of regenerative medicine in primate species, including humans. The goal is to unravel the fundamental biological mechanisms of bone formation unique to non-human and human primates. The broad target audience dovetails with several disciplines both in the academic and private biotech sectors primarily involved in molecular biology, tissue biology, tissue engineering, biomaterial science, and reconstructive, orthopedic, plastic, and dental surgery.

Key Features

Includes outstanding images of undecalcified whole mounted sections

Summarizes non-human primate research - ideal for clinical translation

Reviews methods for creating devices capable of making bone autonomously, i.e. an intrinsically osteo-inductive bioreactor and/or biomaterial

Describes the spontaneous induction of bone formation including a whole spectrum of tissue biology, from basic molecular biology to clear-cut morphology and pre-clinical application in non-human primate species

Intended for audiences in both academic research and the biotech industry

Contents:

Preface/Introduction The Geometric Induction of Bone Formation Ugo Ripamonti and Hari A Reddi

Chapter 1 The New Frontiers in Bone Tissue Engineering: Functionalized Biomimetic Surfaces beyond Morphogens and Stem Cells Ugo Ripamonti and Laura C. Roden

Chapter 2 The Induction of Bone Formation: When and Why Bone Forms and Sometime Repair and Regenerate: The Enigmatic Myth of Bone Tissue Engineering and the Dream of Regenerative Medicine Ugo Ripamonti

Chapter 3 The Induction of Bone Formation and the Osteogenic Proteins of the Transforming Growth Factor- Supergene Family: Pleiotropism and Redundancy Ugo Ripamonti

Chapter 4 Coral-Derived Hydroxyapatite-Based Macroporous Bioreactors Initiate the Spontaneous Induction of Bone Formation in Heterotopic Extraskeletal Sites: Morphological Time Studies Ugo Ripamonti

Chapter 5 Concavities of Crystalline Sintered Hydroxyapatite-Based Macroporous Bioreactors Initiate the Spontaneous Induction of Bone Formation Ugo Ripamonti

Chapter 6 Molecular Pathways Regulating the Geometric Induction of Bone Formation: Synthetizing and Embedding Osteogenic Proteins into Nanotopographic Geometries Raquel Duarte and Ugo Ripamonti

Chapter 7 The Spontaneous Induction of Bone Formation by Intrinsically Osteoinductive Bioreactors for Human Patients: Osteoinductive Hydroxyapatite-Coated Titanium Implants Ugo Ripamonti