Main description:

This book summarizes the development and statistical validation of a guinea pig model as an alternative for potency testing of the viral antigens included in combined vaccines applied in cattle to control the respiratory, reproductive, and neonatal calf diarrhea syndromes. The model allows, in one serum sample, to test the vaccine quality for all the viral antigens included in aqueous as well as in oil-adjuvanted formulations of bovine vaccines. The methodology proposed for the control of bovine herpes virus, parainfluenza, and rotavirus were recommended by CAMEVET as guidelines for the 30 countries in the forum, including the US.

Key Features

Reviews combined vaccines used for cattle

Summarizes animal models used for vaccine testing

Focuses on bovine herpesviruses, rotaviruses, parainfluenza, and bovine viral diarrhea virus

Provides guidance on the effectiveness of the Guinea Pig model for testing vaccine immunogenicity

Contents:

Chapter 1 - Vaccination of cattle

Chapter 2 - Guinea pig model to test the potency of IBR vaccines

Chapter 3 - Guinea pig model to test the potency of Rotavirus vaccines

Chapter 4 - Guinea pig model to test the potency of Bovine Parainfluenza Type 3 Virus vaccines

Chapter 5 - Guinea pig model to test the potency of BVDV vaccines

Chapter 6 - Guinea pig model application

References