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MORE ABOUT THIS BOOK
Main description:
Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. The second edition includes the current status of the field and descriptions of a number of novel co-chaperones that have been recently identified. This new edition has a strong focus on the role of co-chaperones in human disease and as putative drug targets. The book will be a resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.
Contents:
Preface
List of Contributors
About the Editors
1
GrpE, Hsp110/Grp170, HspBP1/Sil1 and BAG domain proteins: Nucleotide exchange factors for Hsp70 molecular chaperones
Andreas Bracher and Jacob Verghese
2
Functions of the Hsp90-Binding FKBP Immunophilins
Naihsuan Guy, Yenni A. Garcia, Jeffrey C. Sivils, Mario D. Galigniana, and Marc B. Cox
3
Hsp70/Hsp90 organising protein (Hop): beyond interactions with chaperones and prion proteins
Swati Baindur-Hudson, Adrienne L. Edkins, and Gregory L. Blatch
4
Specification of Hsp70 function by Type I and Type II Hsp40
Douglas M. Cyr and Carlos H. Ramos
5
Cdc37 as a Co-chaperone to Hsp90
Stuart K Calderwood
6
p23 and Aha1
Alexandra B Rehn and Johannes Buchner
7
UCS proteins: chaperones for myosin and co-chaperones for Hsp90
Weiming Ni and Odutayo O. Odunuga
8
Chaperonin - Co-chaperonin Interactions
Aileen Boshoff
9
Co-chaperones of the mammalian endoplasmic reticulum
Armin Melnyk, Heiko Rieger and Richard Zimmermann
10
The evolution and function of co-chaperones in mitochondriaNeta Regev-Rudzki, Kip Gabriel and Dejan Bursac
11
CHIP: a co-chaperone for degradation by the proteasome
Adrienne L. Edkins
12
The role of HSP70 and its co-chaperones in protein misfolding, aggregation and disease
Emma J. Duncan, Michael E. Cheetham, J. Paul Chapple, and Jacqueline van der Spuy
Index
PRODUCT DETAILS
Publisher: Springer (Springer International Publishing AG)
Publication date: January, 2015
Pages: 350
Weight: 606g
Availability: Available
Subcategories: Biochemistry, General Issues
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