Main description:

The urgent need for the development of early tumor diagnosis and effective anti-tumor therapies remains. This work intends to provide a relatively broad audience with a novel approach for the development of cancer diagnostics and targeted therapeutics, based on recently proved hypotheses. It provides coverage of the most important aspects of a selected domain of tumor immunology, namely the characteristics and potential capacity of the tumor infiltrating B lymphocytes.

Feature:

Introduces the readers to the highly interesting matter of therapeutic drug discovery, based on a great variety of possibilities in antibody engineering and biotechnology

Researchers, clinicians, medical students (and eventually some patients with interest) will be guided through this exiting methodological pathway. By supplying the readers with recent results concerning the feasibility of the whole process, it will give them hope that cancer might someday be detected and cured within a reasonable time

Contents:

Chapter 1. Tumor infiltrating T lymphocytes: Brief summary about the characteristics and role of tumor infiltrating T lymphocytes.

Chapter 2. Tumor infiltrating B lymphocytes: Characteristics, potential capacity and role of tumor infiltrating B lymphocytes.

Chapter 3. B lymphocytes in different solid tumors: Melanomas, breast carcinomas, ovarian carcinomas, neuroblastoma

Chapter 4. Results of immunoglobulin repertoire analysis: Fetal and adult normal B cells compared to B cells from tumor tissues.

Chapter 5. Potential capacity of natural human antibodies for therapeutic approaches

Chapter 6. Potential capacity of autoantibodies for therapeutic approaches

Chapter 7. Potential capacity, benefits and drawbacks of different antibody fragments for therapeutic approaches

Chapter 8. Methodological arsenal of antibody engineering and biotechnology for developing novel immunoconjugates for diagnostics and therapeutics.

Chapter 9. The secret of tumor infiltrating lymphocytes: novel tumor-specific target antigens revealed.

Chapter 10. The "sleeping beauty" might be awaked: A special family of tumor associated molecules, the gangliosides.

Chapter 11. Achievements and future prospects for novel tumor diagnostics and therapeutics

Chapter 12. The benefits of targeted therapeutics to defeat cancer.