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MORE ABOUT THIS BOOK
Main description:
A cutting-edge review of the major research areas of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses.
Contents:
Microbial Pathogenesis and the Discovery of Toll-Like Receptor Function
Bruce Beutler
Dendritic Cells: Targets for Immune Modulation by Microbes and Immunologists
Bali Pulendran, Anshu Agrawal, Stephanie Dillon, and Sudhanshu Agrawal
Achieving Transcriptional Specificity in NF-kB-Dependent Inflammatory Gene Expression
Gioacchino Natoli
Adjuvants and the Initiation of T-Cell Responses
Matthew F. Mescher, Julie M. Curtsinger, and Marc Jenkins
Mechanism for Recognition of CpG DNA
Kiyoshi Takeda, Hiroaki Hemmi, and Shizuo Akira
CpG ODN As a Th1 Immune Enhancer for Prophylactic and Therapeutic Vaccines
Arthur M. Krieg and Heather L. Davis
Modified Bacterial Toxins
Ed C. Lavelle, Olive Leavy, and Kingston H. G. Mills
Glycosylphosphatidylinositol Anchors As Natural Immunological Adjuvants Derived From Protozoan Parasites
Ricardo T. Gazzinelli, Catherine Ropert, Igor C. Almeida, Joao S. Silva, and Marco A. Campos
The Immunomodulatory Glycan LNFPIII/Lewis X Functions As a Potent Adjuvant for Protein Antigens
Mitsuhiro Okano, Kazunori Nishizaki, Akram Da'dara, Paul Thomas, Michele Carter, and Donald A. Harn, Jr.
Immune and Antiviral Effects of the Synthetic Immunomodulator Murabutide: Molecular Basis and Clinical Potential
George M. Bahr
Effect of QS-21 on Innate and Adaptive Immune Responses
Charlotte Read Kensil, Gui Liu, Christine Anderson, and James Storey
Monophosphoryl Lipid A and Synthetic Lipid A Mimetics As TLR4-Based Adjuvants and Immunomodulators
Jory Baldridge, Kent Myers, David Johnson, David Persing, Christopher Cluff, and Robert Hershberg
Microparticles and DNA Vaccines
Kimberly Denis-Mize, Manmohan Singh, Derek T. O'Hagan, Jeffrey B. Ulmer, and John J. Donnelly
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: December, 2010
Pages: 298
Weight: 441g
Availability: Available
Subcategories: Immunology
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