Main description:

Zika Virus Impact, Diagnosis, Control, and Models: Volume Two: The Neuroscience of Zika examines diagnosis, vaccines, and potential therapy methods for Zika virus syndrome. The book also details the neuroscience of Guillain-Barre syndrome, its effects and neuromuscular rehabilitation. It is designed to help readers better understand detection, therapies for Zika virus, preventative vaccines, diagnosis and associated microcephaly. Chapters on models enable further research and understanding. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.

Contents:

Section 1 - Methods, Biomarkers, and Diagnosis 1. Imaging Zika virus infection 2. Use of CRISPR: applications to flaviviruses 3. Methods of investigating neurotoxicity of larvicides: applications of systems biology 4. Methods for the detection of Zika virus infectivity

Section 2 - Vector Control, Vaccines, Pharmacology 5. Vector control and Zika virus: a focus on mosquitoes 6. Vector control: a focus on rural household containers: applications to Zika virus 7. Zika virus Vaccines: an overview 8. Novel treatment with 2,8-bis(trifluoromethyl)quinoline analogs in Zika infection in vitro 9. Zika virus use of human neutralizing antibody in microcephaly prevention: a modelling system 10. Policies on Zika virus Control

Section 3 - Novel and Non-Pharmacologic Therapies 11. Role of the pediatric neurologist in treating Zika virus syndrome 12. 25-Hydroxycholesterol usage in Zika Virus Infection 13. Screening and inhibition of the flavivirus NS2B-NS3 protease: application to zika virus 14. Gene silencing and applications to zika virus 15. Screening phytochemicals that react against Zika virus

Section 4 - Models and Modelling 16. Guinea pig model of Zika virus: features and applications 17. Rat model of Zika virus: features and applications 18. Mouse model of Zika virus: features and applications 19. Modelling Zika virus in the USA 20. Modelling Zika virus infection in laboratory animals: impact on neurological systems

Section 5 - Neuroscience of Guillain-Barre Syndrome 21. Severe Guillain-Barre Syndrome 22. Plasmablasts, plasma and neurotoxic antibodies in Guillain-Barre syndrome 23. Oxidative stress in Guillain-Barre Syndrome and linkage with neurology 24. Neuromuscular effects and rehabilitation in Guillain-Barre syndrome 25. Post-infectious demyelinating diseases: Guillain-Barre syndrome and beyond

Section 6 - Neuroscience of Microcephaly 26. Microcephaly and developmental delays 27. Congenital microcephaly: features and risk factors 28. Microcephaly in fetal alcohol syndrome 29. Microcephaly in genetic disorders: the case of MFSD2A and hypomyelination 30. Folate metabolism, 5,10-methenyltetrahydrofolate synthetase and microcephaly

Section 7 - International Aspects 31. Zika Virus in Honduras 32. Zika Virus in Uganda 33. Zika Virus in Jamaica 34. Zika virus in Mozambique 35. Zika virus in Brazil

Section 8 - Case Reports 36. Case reports: Zika and Chikungunya virus infection 37. Case reports: Zika virus neuroretinitis 38. Case reports: Zika virus infection in Singapore 39. Case reports: Coinfection with Zika virus and dengue-2 viruses 40. Case report: Guillain-Barre and Zika virus infection