Main description:

The present work corresponds to a compilation of independent contributions in the fields of endocrinology, immunity, cancer, neurobiology, and myology. Revision of current advances as well as novel findings in the form of original articles are presented in a balanced fashion. The book has been divided into three sections in line with the main subject: Molecular pathology of immune, inflammatory, and hemostatic disorders; Molecular pathology of endocrine and muscular disorders; and Molecular pathology of cancer: determinants and potential therapies. In the first section, contributing authors take the reader through the molecular pathology of immune responses, inflammation, and hemostasis, by collating an update on systemic autoimmune diseases, the therapeutic potential of statins in hemostasis, the effects of adrenergic stimulation on coagulation, the emerging field of physical burnout due to the mobility restrictions in response to the 2020 SARS-CoV-2 pandemic imposed worldwide, and the success of community-oriented muscular kinesic rehabilitation. The second section presents engaging results from a survey of iodine intake through the diet of pregnant females, an appraisal of the neuroprotective effect of dexmedetomidine, novel evidence on muscle physiopathology, describing the upregulation of CCL5/RANTES during cholestatic liver disease, the fibrotic response emerging in response to cholic and deoxycholic acids, and the altering effects of bile acids in autophagy and mitogenesis. In the third section, a comprehensive revision of cancer literature is offered with an emphasis on melanoma, myeloid-derived suppressor cells, microRNA-based diagnostic approaches, and new avenues for cancer immunotherapy. Altogether, these individual contributions offer a comprehensive and up-to-date outlook of the current state in the field of molecular pathology.

Section 3 Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Contents:

SECTION 1: Molecular pathology of immune, inflammatory, and hemostatic disorders
1. Immune responses at host barriers and their importance in systemic autoimmune diseasesKatina Schinnerling, Hugo A Penny, Jorge A Soto, and Felipe Melo-Gonzalez.
2. Statins and hemostasis: therapeutic potential based on clinical evidenceYolanda Prado, Diego Aravena, Felipe M. Llancalahuen, Cristobal Aravena, Felipe Eltit, Cesar Echeverria, Sebastian Gatica, Claudia A Riedel, and Felipe Simon.
3. Effects of adrenergic receptor stimulation on human hemostasis: A systematic reviewSebastian Gatica, Diego Aravena, Cesar Echeverria, Juan F Santibanez, Claudia A Riedel, and Felipe Simon.
4. 1-adrenergic stimulation increases platelet adhesion to endothelial cells mediated by TRPC6Felipe M. Llancalahuen, Alejando Vallejos, Diego Aravena, Yolanda Prado, Sebastian Gatica, Carolina Otero, and Felipe Simon.
5. Physical Activity, Burnout, and Engagement in Latin American Students of Higher Education during the COVID-19 PandemicAndrea Gonzalez, Oscar Achiardi, Martina Valencia, and Claudio Cabello-Verrugio.
6. Small plastics, big inflammatory problemsYolanda Prado, Cristobal Aravena, Diego Aravena, Felipe Eltit, Sebastian Gatica, Claudia A. Riedel, and Felipe Simon.
7. Impact of a community-based pelvic floor kinesic rehabilitation program on the quality of life of Chilean adult women with urinary incontinenceEduardo Cifuentes-Silva, Natalia Valenzuela-Duarte, Ismael Canales-Gajardo, and Claudio Cabello-Verrugio.
SECTION 2: Molecular pathology of endocrine and muscular disorders
1. Iodine intake based on a survey from a cohort of women at their third trimester of pregnancy from the Bosque County ChileMaria Cecilia Opazo, Camilo Fuentes Pena C, Luis Mendez, Diana Rojas, Daniel Aguayo, Juan Carlos Oyanedel, Rodrigo Moreno-Reyes, Nelson Wolhk, Alexis M. Kalergis, and Claudia A. Riedel.
2. Appraisal of the neuroprotective effect of dexmedetomidine: a meta-analysisSebastian Gatica, Cristobal Aravena, Yolanda Prado, Diego Aravena, Cesar Echeverria, Juan F Santibanez, Claudia A Riedel, and Felipe Simon.
3. Bile acids alter the autophagy and mitogenesis in skeletal muscle cellsFranco Tacchi, Josue Orozco-Aguilar, Mayalen Valero-Breton, and Claudio Cabello-Verrugio.
4.Upregulation of CCL5/RANTES gene expression in the diaphragm of mice with cholestatic liver diseaseVania Morales, Andrea Gonzalez, and Claudio Cabello-Verrugio.
5. Differential fibrotic response of muscle fibroblasts, myoblasts, and myotubes to cholic and deoxycholic acidsLuis Maldonado, Josue Orozco-Aguilar, MayalenValero-Breton, Franco Tacchi, Eduardo Cifuentes-Silva, and Claudio Cabello-Verrugio.
6. BMAL1 regulates glucokinase expression through E-box elements in vitroPaula Llanos, Patricio Ordenes, David B. Rhoads, Juan F. Santibanez, Maria Garcia-Robles, and Carola Millan.
SECTION 3: Molecular pathology of cancer: determinants and potential therapies
1. Correlation between endoglin and malignant phenotype in human melanoma cells: analysis of hsa-mir-214 and hsa-mir-370 in cells and their extracellular vesiclesLidia Ruiz-Llorente, Maria Jesus Ruiz-Rodriguez, Claudia Savini, Teresa Gonzalez-Munoz, Erica Riveiro-Falkenbach, Jose L. Rodriguez-Peralto, Hector Peinado, and Carmelo Bernabeu.
2. Increase in Frequency of Myeloid-Derived Suppressor Cells in the Bone Marrow of Myeloproliferative Neoplasm: Potential Implications in MyelofibrosisSuncica Kapor, Sanja Momcilovic, Slobodan Kapor, Slavko Mojsilovic, Milica Radojkovic, Milica Apostolovic, Branka Filipovic, Mirjana Gotic, Vladan Cokic, and Juan F Santibanez.
3. The "Ins and Outs" of prostate specific membrane antigen (PSMA) as specific target in prostate cancer therapyFelipe Eltit, Nicole Robinson, Pak Lok Ivan Yu, Mitali Pandey, Jerome Lozada, Yubin Guo, Manju Sharma, Dogancan Ozturan, Laetitia Ganier, Eric Belanger, Nathan A. Lack, David M. Perrin, Michael E. Cox, and S. Larry Goldenberg.
4. Transforming Growth Factor- 1 in Cancer Immunology: opportunities for immunotherapyVictor H. Villar, Tijana Suboticki, Dragoslava Dikic, Olivera Mitrovic Ajtic, Felipe Simon, and Juan F. Santibanez.