Main description:

Exciting new "biologic" therapies for treating leukemia are appearing so rapidly that clinicians often find it difficult to make informed decisions about their use when making patient treatment decisions. Biologic Therapy of Leukemia summarizes and reviews all the available data concerning these cutting-edge biologic therapies so that practicing clinicians can make the correct patient-care choices. Here the busy physician will find in one convenient place crucial information on the uses and limitations of the major biologic therapies for leukemia, the different biologic strategies for its treatment, the management of patients being treated with such biologic agents, and the current and future role of emerging biologic agents.

Contents:

Part I: Immunotherapy

Human Leukemia-Derived Dendritic Cells as Tools for Therapy
David Claxton

The Graft vs Leukemia Effect
Brian J. Bolwell

Unconjugated Monoclonal Antibodies
Matt Kalaycio

Drug Immunoconjugate Therapy of Acute Myeloid Leukemia
Arthur E. Frankel, Bayard L. Powell, Eli Estey, and Martin S. Tallman

Radiolabeled Monoclonal Antibodies
John M. Burke and Joseph G. Jurcic

Part II: Cytokines

Interferons
Thomas Fischer

Interleukin-2 Treatment of Acute Leukemia
Peter Kabos and Gary J. Schiller

Part III: Targeted Therapeutics

Antisense Therapy
Stanley R. Frankel

Signal Transduction Inhibitors
Michael E. O'Dwyer and Brian J. Druker

P-Glycoprotein Inhibition in Acute Myeloid Leukemia
Thomas R. Chauncey

Targeting the Apoptotic Machinery as a Potential, Antileukemic Strategy
Benjamin M. F. Mow and Scott H. Kaufmann

Part IV: Differentiation Agents

Arsenicals: Past, Present, and Future
Chadi Nabhan and Martin S. Tallman

All-Trans-Retinoic Acid in the Treatment of Acute Promyelocytic Leukemia
Pierre Fenaux and Laurent Degos

Part V: Gene Therapy

Gene Therapy
Paul J. Orchard and R. Scott McIvor

Index