Main description:

This succinct resource provides an ideal balance of the biology and practical therapeutic strategies for classic and non-classic BCR-ABL-negative myeloproliferative neoplasms. Utilizing current World Health Organization nomenclature, classification, and diagnostic criteria, international experts have assembled to convey the most up-to-date knowledge in this rapidly evolving field. The opening chapters cover the diagnosis and classification, genetics, cytogenetic findings, and prognostic factors of MPNs. Further chapters explore therapies specific to the different disease entities, including polycythemia vera, essential thrombocytopenia, myelofibrosis, and eosinophilic disorders, and mastocytosis. Unique areas of discussion include JAK2 inhibitor therapy, hematopoietic stem cell transplantation, and blastic transformation. A valuable reference for practicing hematologists, this forefront book enriches our understanding of recent discoveries and their impact on conventional and investigational treatments.

Contents:

Chapter 1 - Diagnosis and Classification of the BCR-ABL- negative Myeloproliferative Neoplasms James W. Vardiman and Carlos E. Bueso-Ramos
Chapter 2 - Genetics of the Myeloproliferative Neoplasms
Omar Abdel-Wahab and Ross L. Levine
Chapter 3 - Cytogenetic Findings in Classic Myeloproliferative Neoplasms
John T Reilly
Chapter 4 - Prognostic Factors in Classic Myeloproliferative Neoplasms
Francisco Cervantes and Juan-Carlos Hernandez-Boluda
Chapter 5 - Therapy of Polycythemia Vera and Essential Thrombocythemia
Guido Finazzi and Tiziano Barbui
Chapter 6 - Conventional and Investigational Therapy for Primary Myelofibrosis
Giovanni Barosi
Chapter 7 - Hematopoietic Cell Transplantation for Myelofibrosis
Daniella M.B. Kerbauy and H.Joachim Deeg
Chapter 8 - JAK2 Inhibitors as Therapy for Classic Myeloproliferative Neoplasms
Fabio P S Santos and Srdan Verstovsek
Chapter 9 - Blastic Transformation of Classic Myeloproliferative Neoplasms
Ruben A. Mesa
Chapter 10 - Eosinophilic Disorders: Differential Diagnosis and Management
Jason Gotlib
Chapter 11 - Pathogenesis, Diagnosis, Classification, and Management of Systemic Mastocytosis
Animesh Pardanani and Ayalew Tefferi