Main description:

The current explosion of new areas of controversy in the treatment of acute lymphocytic leukemia in adults and young adults makes this comprehensive book a much needed reference for hematologists and oncologists. This book assembles leading authorities from around the globe to cover the full spectrum of ALL subtypes and their treatments. Specific topics of discussion include indications for allogeneic bone marrow transplant in first complete remission, the role of minimal residual disease in making treatment decisions, the treatment of young adults, and the treatment of Philadelphia chromosome positive ALL with the advent of the tyrosine kinase inhibitors.

This is the first book to focus exclusively on the adult ALL patient. It provides a complete overview of diagnosis, molecular pathogenesis, evaluation, and treatment for this important patient population.

Contents:

Chapter 1 A Perspective on the Treatment of Acute Lymphoblastic Leukemia
Charles A Schiffer

Chapter 2 Clinical Features and Making the Diagnosis
Olga Frankfurt
LoAnn Peterson
Martin S. Tallman

Chapter 3 The Biology of Adult Acute Lymphoblastic Leukemia
Jerald Radich
Olga Sala

Chapter 4 Minimal Residual Disease in Acute Lymphoblastic Leukemia
Patrick A. Zweidler-McKay
Michael J. Borowitz

Chapter 5 Cytogenetics
Anthony V. Moorman
Christine J. Harrison

Chapter 6 Acute Lymphoblastic leukemia: Epidemiology
Matthew Hourigan
Anthony H. Goldstone

Chapter 7 Prognostic Factors in Acute Lymphoblastic Leukemia
Adele K. Fielding

Chapter 8 The Generalized Care of the Patient with Acute Lymphoblastic Leukemia
Anthony R. Mato
Alicia K. Morgans
Selina M. Luger

Chapter 9 Treatment of Acute Lymphoblastic Leukemia in Middle-Age and Older Adults
Vaishalee Kenkre
Richard A. Larson

Chapter 10 Pharmacology of Acute Lymphoblastic Leukemia Therapy
Paul M. Barr
Richard J. Creger
Nathan A. Berger

Chapter 11 Assessment of Response to Treatment
Christopher A. Fox
A.K. McMillan

Chapter 12 T-cell Acute Lymphoblastic Leukemia
Andrei R. Shustov
Frederick R. Appelbaum

Chapter 13 Burkitt Leukemia and Lymphoma
Kevin A. David
Mark Roberts
LoAnn Peterson
Andrew M. Evens

Chapter 14 Treatment of Acute Lymphoblastic Leukemia in Young Adults
Nicolas Boissel
Francoise Huguet
Herve Dombret

Chapter 15 Treatment of Philadephia Chromosome Positive Acute Lymphoblastic Leukemia
Deborah Thomas

Chapter 16 Molecular Therapies
Camille Abboud

Chapter 17 Treatment of Relapsed/ Refractory Acute Lymphoblastic Leukemia
Dan DeAngelo

Chapter 18 Allogenic Stem Cell Transplantation for Acute Lymphoblastic Leukemia in Adults
David I. Marks

Chapter 19 Hematopoietic Stem Cell Transplantation in Philadelphia-positive Acute Lymphoblastic Leukemia
Christy J. Stotler
Edward Copelan

Chapter 20 Special Challenges: Genetic polymorphisms and therapy
Maja Krainovic

Chapter 21 Late Consequences of Therapy of Acute Lymphoblastic Leukemia
Mark R. Litzow

Chapter 22 Immunotherapy for Acute Lymphocytic Leukemia
Jacalyn Rosenblatt
David Avigan

Chapter 23 Unique Subtypes in Acute Lymphoblastic Leukemia
Elisabeth Paietta