Main description:

The rapid growth in the number of options available for the management of colorectal cancer presents the clinician with new opportunities and new complexities. An explosion of understanding in the basic science that underlies both the disease and its potential therapies has translated into remarkable technological advances that can now be applied. So many specialties and subspecialties have now been brought to bear that it is appropriate to attempt to bring the expertise from these areas together in one volume, so that practitioners in one aspect of colorectal cancer management can maintain knowledge and expertise regarding the capabilities of other colleagues working in this disease. Colo rectal Cancer: Multimodality Management provides a concise, focused, and current review of the methodological and technological advances that have recently occurred in the management of colorectal cancer. The book has been divided into six basic parts. The first part, dealing with epidemiology and prevention, focuses on the molecular genetic events that occur in the development of colorectal cancer, as well as on our understanding of dietary and environmental factors, and possible strategies for prevention. Part II focuses on both diagnos tic and therapeutic radiology in the management of colorectal cancer, dealing with innumer able advances in imaging, and with the progress in the science and art of radiation therapy. The third section deals with the surgical aspects of management of colorectal cancer, starting with surgical pathology.

Contents:

Part I. Epidemiology/Prevention

Biology and Molecular Genetics of Colorectal Cancer
Scott K. Kuwada, Deborah W. Neklason, and Randall W. Burt

Epidemiological Trends in Colorectal Cancer
Susan M. Talbot and Alfred I. Neugut

Dietary and Lifestyle Influences on Colorectal Carcinogenesis
Charles S. Fuchs

Screening and Surveillance
Arnold J. Markowitz

Chemoprevention of Colorectal Cancer
Monica M. Bertagnolli

Management of Hereditary Colon Cancer Syndromes
Miguel A. Rodriguez-Bigas and Nicholas J. Petrelli

Part II. Diagnostic and Therapeutic Radiology

Overview of CT, MRI, and Ultrasound in the Imaging and Staging of Colorectal Cancer
David J. Vining

Virtual Colonoscopy for Colorectal Cancer Screening and Surveillance
David T. Rubin and Abraham H. Dachman

Preoperative Staging of Rectal Cancer: Endorectal Ultrasound and Endorectal MRI
Spiros Hiotis, Sharon Weber, and W. Douglas Wong

Nuclear Medicine in the Diagnosis and Management of Colorectal Cancer
Stanley J. Goldsmith and Lale Kostakoglu

Radiation Therapy of Resectable Rectal Cancer
Nora A. Janjan, Matthew Ballo, Christopher Crane, and Marc Delclos

Management of Locally Unresectable Rectal Cancer
Bruce D. Minsky

Radiation Therapy for Hepatic Metastases
John M. Robertson

Part III. Surgery of Colorectal Cancer

Surgical Pathology of Colorectal Cancer
Carolyn C. Compton

Surgery of Colon Cancer
Alfred T. Culliford IV and Philip B. Paty

Laparoscopy in Colorectal Cancer Management
Heidi Nelson and Bernardo Tisminezky

Management of Cancer in a Polyp
David A. Rothenberger and Julio Garcia-Aguilar

Surgery of Rectal Cancer
Aaron R. Sasson and Elin R. Sigurdson

Conservative Management of Early-Stage Rectal Cancer
Mitchell C. Posner and Glenn D. Steele, Jr.

Surgical Management of Hepatic Colorectal Metastases
William R. Jarnagin and Yuman Fong

Resection of Colorectal Metastases to the Lung
Robert J. Downey

Surgical Management of Peritoneal Surface Spread of Colorectal Cancer
Paul H. Sugarbaker

Cryosurgical Ablation for the Management of Unresectable Hepatic Colorectal Metastases
Gregory D. Kennedy, Fred T. Lee, Jr., David Mahvi, and John E. Niederhuber

Radiofrequency Ablation of Colorectal Metastases to the Liver
Douglas L. Fraker

Part IV. Medical Oncology

5-Fluorouracil and Its Biomodulation in the Management of Colorectal Cancer
Jean L. Grem

Clinical Implications of Dihydropyrimidine Dehydrogenase on 5-Fluorouracil Pharmacology
Robert B. Diasio

Oral Fluoropyrimidines in Colorectal Cancer
John L. Marshall

Irinotecan in the Treatment of Colorectal Cancer
Leonard B. Saltz

Oxaliplatin in the Treatment of Colorectal Cancer
Stacy D. Jacobson, Steven R. Alberts, and Richard M. Goldberg

TS Inhibitors and Antifolates
Hugo E. R. Ford and David Cunningham

Adjuvant Therapy for Colon Cancer
Kyle Holen and Leonard B. Saltz

Hepatic Artery Infusion
M. Margaret Kemeny and Nancy E. Kemeny

Intraportal and Intraperitoneal Chemotherapy for Colon Cancer
Werner Scheithauer

Molecular Markers of Chemotherapy Resistance in Colorectal Cancer
Peter V. Danenberg

Part V. Supportive Management

Cancer Pain Syndromes in Colorectal and Anal Cancers
Nathan I. Cherny

Pain Management in Colorectal and Anal Cancers
Nathan I. Cherny

Sexuality and Fertility in Patients with Colorectal Cancer
Megan P. Fleming

Complementary and Alternative Medicine Approaches in Colorectal Cancer
Andrew J. Vi