Main description:

In human solid tumors, nodal status is the most important prognostic indicator for patient outcome. Recent developments in the sentinel lymph node concept have resulted in new procedures to define the first draining node as the primary gateway through which the cancer will spread. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System, a panel of international authorities takes an in-depth look at the role of the lymphovascular system in the spread of cancer. The authors summarize the findings of the Second International Symposium on Cancer Metastasis: Basis for Rational Therapy summit. Specifically, the book presents important developments in the biology and clinical understanding of cancer metastasis, describes the relationship between tumor microenvironment and proliferation, and defines the process of lymphangiogenesis and angiogenesis with special reference to cancer metastasis. From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System provides oncologists, radiologists, and cancer researchers the necessary information to study and develop new strategies to curb the process of metastasis.

Contents:

Introduction Stanley P. L. Leong Part I. Tumor Microenvironment and Proliferation Chapter 1 Dynamic Reciprocity Between Tumor Cells and the Microenvironment - Mina J. Bissell Chapter 2 Inflammation as a Regulator of Epithelial Cancer Development - Lisa Coussens Chapter 3 Targeting Molecular Signals in the Tumor Cell Microenvironment - Richard E.B. Seftor Chapter 4 Convergence of Embryonic and Tumorigenic Pathways: Role in Tumor Progression - Mary J.C. Hendrix Part II. Lymphangiogenesis and Angiogenesis Chapter 5 Heme-Lymph Vasculo/Angiogenesis, Angiotumorigenesis, and Tumor Angiogenesis: A Lymphatic System Perspective - Marlys Witte Chapter 6 Model Systems to Study Lymphangiogenesis and Angiogenesis: Lessons for Tumor Biology - Joerg Wilting Chapter 7 Vascular Permeability Factor, Lymphangiogenesis/Angiogenesis, and Cancer Biology - Harold Dvorak Chapter 8 Molecular Events and Clinical Correlations in Tumor and Other Lymphangiogenesis - David Jackson Chapter 9 Tumor Lymphangiogenesis: What We Know and Don't Know - Jonathan Sleeman Part III. Diagnostic Imaging of Cancer Chapter 10 Molecular Imaging of Cancer - Receptors, Angiogenesis and Gene Expression Heiko Schoder Chapter 11 MRI and Ultrasound Imaging of Lymph Node - Robert Mattrey Chapter 12 Molecular Imaging of the Sentinel Lymph Node - Anne Wallace Chapter 13 Lymphatic Dysfunction and Scintigraphy in Cancer Patients - Edwin Glass Chapter 14 Molecular Imaging of Neuroendocrine Cancer by fusionSPECT/CT - Alain Pecking Chapter 15 Concepts and Tools of Imaging Cancer - Farhard Daghigian Part IV. Therapeutic Targeting of the Lymphovascular System Chapter 16 Therapeutic Targeting of the Lymphovascular System - Jeffrey Gershenwald Chapter 17 Targeted Introduction of Substances into the Lymph Nodes for Endolymphatic Therapy - Peter Hirnle Chapter 18 Targeting Lymphovascular Endothelium with Anti-VEGFR-3 Monoclonal Antibodies - Bronislaw Pytowski Chapter 19 Radioimmunotherapy for Cancer - Andrew Raubitschek Chapter 20 Animal Models to Study Lymphatic and Vascular Metastasis - David Nathanson and Ann Chambers Part V: Molecular Mechanisms of Metastasis Chapter 21 Early Development of Micrometastasis in Tumor-Draining Regional Lymph Nodes: Can They Be Predicted - Dave S. B. Hoon Chapter 22 Micrometastasis in Patients with Solid Epithelial Tumors - Klaus Pantel Chapter 23 Imaging Tumor Metastasis and Dormancy in Experimental Models -Ann Chambers Chapter 24 Chemokine Receptors and Organ-Specific Metastasis - Bernard Homey Chapter 25 Tumor and Lymph Node Lymphangiogenesis: Impact on Metastasis - Michael Detmar Chapter 26 Role of the Tumor Microenvironment on Tumor Cell Survival and Metastasis - David Cheresh Chapter 27 Treg, Chemokines and other Small Molecules: Role in Metastasis and its Prevention - Marty Mihm Chapter 28 Breast Cancer Metastasis to the Brain - Patricia Steeg Chapter 29 Chemokines, Lymphatics and Metastasis - Robert Ferris and Timothy