Main description:

A clear and comprehensive account of how genetic abnormalities, neurobiology, and neuropsychology work together to manifest cognitive-behavioral dysfunction. The authors review the current status of research in autosomal disorders that produce cognitive-behavioral dysfunction and syndromal and nonsyndromal disorders that produce mental retardation. Comprehensive and up-to-date, Genetics and Genomics of Neurobehavioral Disorders integrates the molecular, genomic, neuropsychological, and neurobehavioral factors that produce learning disabilities and mental retardation into a coherent framework for the understanding and assessment of neurobehavioral disorders.

Contents:

Part I. Introduction and Overview

The Genetics and Genomics of Neurobehavioral Disorders: Historical Introduction and Overview
Gene S. Fisch

Neuroanatomical Considerations Specific to the Study of Neurogenetics
Albert M. Galaburda and J. Eric Schmitt

Modeling Cognitive Disorders: From Genes to Therapies
Rui M. Costa, Ype Elgersma, and Alcino J. Silva

What Can the Study of Behavioral Phenotypes Teach Us About the Pathway from Genes to Behavior?
Jonathan Flint

Part II. Autosomal Disorders and Neurobehavioral Dysfunction

The Central Nervous System in Neurofibromatosis Type 1
Nancy Ratner and Kathryn North

Prader-Willi and Angelman Syndromes: Cognitive and Behavioral Phenotypes
Elisabeth M. Dykens and Suzanne B. Cassidy

Tuberous Sclerosis
Julian R. Sampson and Julia C. Lewis

Behavioral Phenotype in Velo-Cardio-Facial Syndrome
Kieran C. Murphy

Williams-Beuren Syndrome
Monica Bayes and Luis A. Perez Jurado

Behavioral Phenotype in Myotonic Dystrophy (Steinert's Disease)
Jean Steyaert

Part III. X-Linked Nonsyndromal Disorders and Neurobehavioral Dysfunction

Genetics of X-Linked Mental Retardation
Jamel Chelly and Ben C. J. Hamel

Nonsyndromal Mental Retardation Associated with the FRAXE Fragile Site and the FMR2 Gene
Jozef Gecz and Gene S. Fisch

Part IV. X-Linked Syndromal Disorders and Neurobehavioral Dysfunction

ATR-X Syndrome
Takahito Wada and Richard J. Gibbons

The Fragile X Syndrome and the Fragile X Mutation
Mark C. Hirst and Gene S. Fisch

Rett Syndrome: Clinical-Molecular Correlates
Alan K. Percy, Joanna Dragich, and N. Carolyn Schanen

Index