Main description:

In Glutamate and Addiction, world-renowned scientific experts critically review all of the evidence for the role of glutamatergic systems in opiate, stimulant, and alcohol addiction. Using a variety of pharmacological, biochemical, genetic, and brain imaging techniques, these investigators show precisely how glutamate affects such addictions and how modifying certain elements of the glutamatergic system appear to alleviate particular components of addiction. Their survey takes in both clinical approaches using medications that influence glutamate and cutting-edge preclinical approaches that manipulate specific subtypes of glutamate receptors or specific substrates of the "glutamate cascade" to determine their roles in various addictive states.

Contents:

I. Introduction: Physiology and Pharmacology of Glutamate
Philip H. Sheridan, Forrest F. Weight, and Barbara H. Herman, Section Editors

Molecular Pharmacology and Physiology of Glutamate Receptors
Karin Borges and Raymond Dingledine

Pharmacology of Glutamate Receptors
Jeffrey M. Witkin, Rafal Kaminski, and Michael A. Rogawski

Glutamate and Neurotoxicity
B. Joy Snider and Dennis W. Choi

Maturational Regulation of Glutamate Receptors and Their Role in Neuroplasticity
Russell M. Sanchez and Frances E. Jensen

Role of the NMDA Receptor in Neuronal Apoptosis and HIV-Associated Dementia
Marcus Kaul and Stuart A. Lipton

II. Glutamate: Stimulant Drugs of Abuse (Cocaine, Amphetamine, Methamphetamine)
Jerry Frankenheim and Barbara H. Herman, Section Editors

Role of Glutamate and Nitric Oxide in the Acquisition and Expression of Cocaine-Induced Conditioned Increases in Locomotor Activity
Agu Pert, Robert M. Post, and Susan R. B. Weiss

Interactions of Dopamine, Glutamate, and GABA Systems in Mediating Amphetamine- and Cocaine-Induced Stereotypy and Behavioral Sensitization
Ralph Karler, David K. Thai, and Larry D. Calder

Addiction and Glutamate-Dependent Plasticity
Marina E. Wolf

Glutamate and Dopamine Interactions in the Motive Circuit: Implications for Craving, David A. Baker, Jennifer L. Cornish, and Peter W. Kalivas

Glutamate Cascade from Metabotropic Glutamate Receptors to Gene Expression in Striatal Neurons: Implications for Psychostimulant Dependence and Medication
John Q. Wang, Limin Mao, and Yuen-Sum Lau

Glutamate Neurotransmission in the Course of Cocaine Addiction
Luigi Pulvirenti

Glutamate and the Self-Administration of Psychomotor-Stimulant Drugs
Paul Vezina and Nobuyoshi Suto

Roles of Glutamate, Nitric Oxide, Oxidative Stress, and Apoptosis in the Neurotoxicity of Methamphetamine
Jean Lud Cadet

Methamphetamine Toxicity: Roles for Glutamate, Oxidative Processes, and Metabolic Stress
Kristan B. Burrows and Bryan K. Yamamoto

Nitric Oxide-Dependent Processes in the Action of Psychostimulants
Yossef Itzhak, Julio L. Martin, and Syed F. Ali

Effects of Novel NMDA/Glycine-Site Antagonists on the Blockade of Cocaine-Induced Behavioral Toxicity in Mice
Rae R. Matsumoto and Buddy Pouw

Clinical Studies Using NMDA Receptor Antagonists in Cocaine and Opioid Dependence
Adam Bisaga and Marian W. Fischman

The Role of mGluR5 in the Effects of Cocaine: Implications for Medication Development
Mark P. Epping-Jordan

III. Glutamate and Opiate Drugs (Heroin) of Abuse
Barbara H. Herman and Jerry Frankenheim, Section Editors

Role of the Glutamatergic System in Opioid Tolerance and Dependence: Effects of NMDA Receptor Antagonists
Jianren Mao

The Role of NMDA Receptors in Opiate Tolerance, Sensitization, and Physical Dependence: A Review of the Research, A Cellular Model, and Implications for the Treatment of Pain and Addiction
Keith A. Trujillo

Modification of Conditioned Reward by N-Methyl-d-aspartate Receptor Antagonists
Piotr Popik

Morphine Withdrawal as a State of Glutamate Hyperactivity: The Effects of Glutamate Receptor Subtype Ligands on Morphine Withdrawal Symptoms
Kurt Rasmussen

IV. Glutamate and Alcohol Abuse and Alcoholism
Forrest F. Weight and Raye Z. Litten, Section Editors

Alcohol Actions on Glutamate Receptors
Robert W. Peoples

Glutamate and Alcohol-Induced Neurotoxicity
Fulton T. Crews, Joseph G. Rudolph, and L. Judson Chandler

Role of Glutamate in Alcohol Withdrawal Kindling
Howard C. Becker and Nicole Redmond

Alcohol and Glutamate Neurotransmission in Humans: Implications for Reward,