Main description:

Brain Hypoxia and Ischemia explores the various aspects of cell death and survival that are crucial for understanding the basic mechanisms underlying brain hypoxia and ischemia. Chapters focus on a panorama of issues including the role of ion channels/transporters, mitochondria and apoptotic mechanisms, the roles of glutamate/NMDA, mechanisms in penumbral cells and the importance of intermittent hypoxia and gene regulation under these stressful conditions. The volume explores findings from both mammalian and invertebrate model systems and their applicability to human systems and diseases. Careful consideration is also given to differences in hypoxia and ischemia across development.

This volume aims to increase the understanding of these mechanisms and to stimulate research on better diagnosis and treatment of diseases that afflict the brain and potentially other organs when O2 levels are dysregulated. Brain Hypoxia and Ischemia is designed for neuroscientists, clinicians and medical/graduate students for use in both basic research and clinical practice.

Contents:

I. Ion Channels, Transporters and Excitotoxicity.- Regulation of vulnerability to NMDA excitotoxicity during postnatal maturation.- Acidosis, acid-sensing ion channels, and glutamate receptor independent neuronal injury.- Brain ischemia and neuronal excitability.- Critical roles of the Na+/K+-ATPase in apoptosis and CNS Diseases.- Emerging role of water channels in regulating cellular volume during oxygen deprivation and cell death.- A zinc-potassium continuum in neuronal apoptosis.- Mitochondrial ion channels in ischemic brain.- II. Reactive Oxygen Species, and gene expression to behavior.- Perinatal panencephalopathy in premature infants: Is it due to hypoxia-ischemia?.- Effects of intermittent hypoxia on neurological function.- Brainstem sensitivity to hypoxia and ischemia.- Matrix metalloproteinases in cerebral hypoxia-ischemia.- Oxidative stress in hypoxic-ischemic brain injury.- Post-natal hypoxia and the developing brain: Cellular and molecular mechanisms of injury.- Hypoxia-inducible Factor 1.- Transcriptional response to hypoxia in developing brain.- Acute stroke therapy: Highlighting the ischemic penumbra.- Genes and survival to low O2 environment: Potential insights from Drosophila