Main description:

Globally, HIV-associated tuberculosis is one of the most important causes of infection-related death, accounting for one in every three HIV deaths and over 300,000 in 2017 alone. The HIV epidemic has undermined tuberculosis-control efforts in many countries around the world, as the virus has important modifying effects on the pathogenesis, diagnosis, and treatment of TB. The management of HIV-associated TB is also complicated by rapid clinical progression, immune reconstitution inflammatory syndrome, drug-drug interactions, and shared toxicities.

The past two decades have yielded thousands of research publications and review articles on HIV-associated TB. HIV and Tuberculosis: A Formidable Alliance consolidates this massive amount of data into a single resource. With contributions from myriad disciplines, including epidemiology, immunology, public health, and clinical medicine, this book provides well-rounded and thorough coverage that will appeal to researchers and clinicians alike.

Contents:

1. Overview of the HIV-associated tuberculosis epidemicContance A. Benson
2. Epidemiology of Drug-susceptible, Drug-resistant Tuberculosis and HIV in AfricaKogieleum Naidoo and Nikita Naicker
3. Modelling the HIV-associated TB epidemic and the impact of interventions aimed at epidemic controlP.J. Dodd, C. Pretorius, B.G. Williams
4. Immune Responses to Mycobacterium tuberculosis and the impact of HIV infectionCatherine Riou, Cari Stek, Elsa Du Bruyn
5. Clinical Manifestations of HIV-associated tuberculosis in adultsSean Wasserman, David Barr, Graeme Meintjes
6. The tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS)Irini Sereti, Gregory P. Bisson, Graeme Meintjes
7. Diagnosis of HIV-associated tuberculosisAndrew Kerkhoff, Adithya Cattamanchi
8. Recent advances in the treatment of latent tuberculosis infection among adults living with HIV infectionApril C. Pettit, Timothy R. Sterling
9. Treatment of drug-sensitive tuberculosis in persons with HIVAlice K. Pau, Safia Kuriakose, Kelly E. Dooley, Gary Maartens
10. Drug-resistant TB and HIVSara C. Auld, Neel R. Gandhi, James C.M. Brust
11. Co-treatment of tuberculosis and HIV: pharmacologic considerationsEthel D. Weld, Alice K. Pau, Kelly E. Dooley
12. HIV and TB in childrenTonya Arscott-Mills, Ben Marais, Andrew Steenhoff
13. Neurological TB in HIVLouise Bovijn, Regan Solomons, Suzaan Marais