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MORE ABOUT THIS BOOK
Main description:
This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinson's disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts.
Contents:
Enzymes in Poly(ADP-Ribose) Metabolism.- PARP-2: Structure-Function Relationship.- Targeting the Poly (ADP-Ribose) Glycohydrolase (PARG) Gene in Mammals.- DNA Damage Signaling through Poly(ADP-Ribose).- Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity.- Functional Interactions of PARP-1 with p53.- Dynamic Interaction between PARP-1, PCNA and p21waf1/cip1.- PARP-1 as Novel Coactivator of NF-?B in Inflammatory Disorders.- PARP and Epigenetic Regulation.- PARP and the Release of Apoptosis-Inducing Factor from Mitochondria.- Genome Degradation by DNAS1L3 Endonuclease.- NAD: Metabolism and Regulatory Functions.- PARP-1 and the Shape of Cell Death.- Poly(ADP-Ribose) Polymerase (PARP) and Excitotoxicity.- Poly(ADP-Ribose) Polymerase and Ischemia-Reperfusion Injury.- Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Inflammation and Circulatory Shock.- Role of Poly-ADP-Ribosylation in Cancer Development.- PARP Inhibitors and Cancer Therapy.- Poly(ADP-Ribosyl)ation and Aging.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: May, 2006
Pages: 263
Weight: 620g
Availability: Available
Subcategories: Biochemistry, Genetics, Microbiology
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