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MORE ABOUT THIS BOOK
Main description:
The SecretoryPathway The transport ofproteins and lipids from their site ofsynthesis at the endoplasmic reticu- lum (ER) to the cellsurface ismediated by the secretory pathway and isan essential process in eukaryotic organisms. A great variety ofmolecules are extruded from cellsby the action ofthe secretory pathway, including extracellular matrix components that provide the foundation for constructing tissuesand organs. Moreover, this pathway playsa major role in the biogenesisof the plasma membraneand itsexpansion before celldivision. Therefore, withoutsecretion there would be no cells,tissuesor organs, and so it issafeto saythat we oweourvery existence to the secretory pathway. To understand the process ofsecretion we must learn about the organelles that compose the secretory pathway; the ER and Golgi apparatus, and the transport vesicles these or- ganelles produce. The membrane ofthese organelles is primarily synthesized and assembled at the ER but with contributions from mitochondria (phosphatidylethanolamine) and the Golgi apparatus (sphingolipids).
Newly synthesized proteins destined for secretion gain en- try into the secretory pathway by translocation across the ER membrane. This translocation apparatus also integrates proteins into the membrane and establishes their topology with respect to the lipid bilayer (seeChapter 7). Many secretory proteins are covalently modified with oligosaccharides to produce glycoproteins, a biosynthetic process initiated in the ER and continued in the Golgi apparatus. Once proteins are properly folded and modified in the ER, they are allowed to leave and are ushered into COPlI-coated carrier vesiclesforming at specific exit sites (see Chapters 1 and 8).
Contents:
Section I. Compartments and Pathways
1. Overview of Intracellular Compartments and Trafficking Pathways
Andrei A. Tokarev, Aixa Alfonso and Nava Segev
2. How We Study Protein Transport
Mary L. Preuss, Peggy Weidman and Erik Nielsen
3. The Golgi Apparatus
Zhaolin Hua and Todd R. Graham
4. The Endocytic Pathway
Elizabeth Conibear and Yuen Yi C. Tam
5. Regulated Secretion
Naveen Nagarajan, Kenneth L. Custer and Sandra Bajjalieh Section II. Mechanisms
6. Overview of Protein Trafficking Mechanisms
Giancarlo Costaguta and Gregory S. Payne
7. Entry into the Endoplasmic Reticulum: Protein Translocation, Folding and
Quality Control
Sheara W. Fewell and Jeffrey L. Brodsky
8. COP-Mediated Vesicle Transport
Silvere Pagant and Elizabeth Miller
9. Clathrin-Mediated Endocytosis
Peter S. McPherson, Brigitte Ritter and Beverly Wendland
10. Biogenesis of Dense-Core Secretory Granules
Grant R. Bowman, Andrew T. Cowan and Aaron P. Turkewitz
11. Lipid-Dependent Membrane Remodelling in Protein Trafficking
Priya P. Chandra and Nicholas T. Ktistakis
12. Carrier Motility
Marcin J. Wozniak and Victoria J. Allan
13. Tethering Factors
Vladimir Lupashin and Elizabeth Sztul
14. Intracellular Membrane Fusion
Dalu Xu and Jesse C. Hay Section III. Regulation and Coordination with Other Cellular Processes
15. Regulation and Coordination of Intracellular Trafficking: An Overview
Julie Donaldson and Nava Segev
16. Regulation of Protein Trafficking by GTP-Binding Proteins
Michel Franco, Philippe Chavrier and Florence Niedergang
17. Posttranslational Control of Protein Trafficking in the Post-Golgi Secretory
and Endocytic Pathway
&nb
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: February, 2012
Pages: 465
Weight: 712g
Availability: Available
Subcategories: Biochemistry, General Issues, Microbiology
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