Main description:

This brilliant synthesis summarizes all of the recent accomplishments - as well as the ongoing research - in the field of composite tissue transplantation. It includes sections on hand transplantation and vascularized bone marrow transplantation. The volume focuses on immunology and the biotechnology/bioengineering aspects of transplantation surgery, as those two areas have demonstrated the most growth within the last five years in terms of current research.

Contents:

Section I.- The Establishment of Composite Tissue Allotransplantion as a Clinical Reality.- The Evolution of Composite Tissue Allotransplantation: the Twentieth Century Realization of "Cosmas and Damian".- The Impact of the Discovery of Cyclosporine on Transplantation of Composite Tissue Allografts.- The First Limb Transplants with Cyclosporine.- Section II.- Translational Research in Composite Tissue Allotransplantation.- Relative Antigenicity of Allograft Components and Differential Rejection.- On the Road to Tolerance Induction in Composite Tissue Allotransplantation.- Donor-Specific Tolerance.- Immune Tolerance Induction: Basic Concepts for Composite Tissue Allotransplantation.- Section III.- Allograft Survival with Calcineurin Inhibitors.- Long-Term Prevention of Rejection and Combination Drug Therapy.- Locoregional Immunosuppression in Composite Tissue Allografting.- New Approaches to Antibody Therapy.- Section IV.- World Experience of Hand Transplantation-Independent Assessment.- Hand Transplantation: Lyon Experience.- Hand Transplantation: The Louisville Experience.- Hand Transplantation: The Innsbruck Experience.- Section V.- Vascularized Bone Marrow Transplantation.- Vascularized Bone Marrow Transplantation: Pathology of Composite Tissue Transplantation-Induced Graft-Versus-Host-Disease.- Immune Cell Redistribution After Vascularized Bone Marrow Transplantation.- Section VI.- Vascularized Knee Transplantation.- Tracheal Transplantation.- Laryngeal Transplantation.- Face Transplantation.- The Role of Allografts in Lower Extremity Reconstruction.- Skin Allografts in Scalp Reconstruction.- Abdominal Wall Transplantation.- Peripheral Nerve Allotransplantation.- Live-Donor Nerve Transplantation.- Section VII.- Ethical and Policy Concerns of Hand/Face Transplantation.- Ethical Debate on Human Face Transplantation.- Psychosocial Issues in Composite Tissue Allotransplantation.- Composite Tissue Transplantation in the Twenty-First Century.