Main description:

In the second edition of this well-known, comprehensive title on Alzheimer’s Disease, prominent Alzheimer's investigators from throughout the world provide an updated and expanded overview of therapeutics for this devastating disease. Divided into five parts, the book begins with basic research on the neurobiology of cognitive function, offering relevant information on the way the brain encodes and stores data. The second segment covers epidemiology, including the global economic burden and risk factors for developing AD. Section three, greatly expanded from the first edition, explores the full range of issues involved in clinical assessment, while sections four and five cover the transitional stage and treatment options, respectively.

Contents:

Preface

Contributors

Part I Scientific Background of Alzheimer’s Disease

1 Genetics of Alzheimer’s Disease and Related Disorders

John Hardy

2 Neuropathology of Alzheimer’s Disease

Christian Schultz, Kelly Del Tredici, and Heiko Braak

3 Oxidative Stress in the Development of Alzheimer’s Disease

and Other Dementias

Domenico Praticò

4 Metabolism and Alzheimer’s Disease

John P. Blass

Part II Epidemiology

5 Alzheimer’s Disease: Epidemiological and Statistical Data

Brigitte Zoeller Richter and Ralph W. Richter

6 The Economic Burden of Alzheimer’s Disease and Dementia

Anders Wimo and Bengt Winblad

7 Potential and Established Risk Factors for Alzheimer’s Disease

Brigitte Zoeller Richter

Part III Clinical Assessment

8 Medical Diagnosis and Workup of Alzheimer’s Disease

Ralph W. Richter

9 Neuroimaging Techniques: CT, MRI, SPECT, PET

Norman L. Foster

10 Computer-assisted cognitive assessment & enhancement (K. Wesnes, MD, UK)

11 Normal Pressure Hydrocephalus (P. Reyes, Prof., San Antonio, TX & R.W. Richter, Prof. Tulsa, OK)

12 Interface between depression and cognitive impairment (D.P. Devanand, Prof., Columbia U, NY)

13 Insulin, Diabetes, Alzheimer Disease – the interplay (S. Kraft, Prof. U Seattle/WA)

AD and the eye (retinal amyloid plaques)

14 Inflammatory and immunological aspects of dementia (D. Morgan, Prof., U South Florida)

15 Non pharmacological interventions in dementia (A. Burns, Prof. U Manchester/UK)

16 Biological Markers in Alzheimer’s Disease

Ramon Diaz-Arrastia and Fred Baskin

17 The Neuropsychology of Alzheimer’s Disease

Kirsten I. Taylor and Andreas U. Monsch

18 Vascular Cognitive Impairment in Clinical Practice

Kenneth Rockwood and Timo Erkinjuntti

19 Lewy Body Disease

Robert Barber, Jane Newby, and Ian G. McKeith

20 Frontotemporal Lobe Dementia

Malgorzata Franczak, Diana Kerwin, and Piero Antuono

Part IV The Transitional Stage

21 Mild Forgetfulness: Distinguishing Early AD from Normal Aging

Scott A. Small

16 Mild Cognitive Impairment: What the Physician Should Know

Brigitte Zoeller Richter

vii

22 Diagnosis of Predementia AD in a Clinical Setting

Pieter Jelle Visser

23Loss of Olfactory Function in Patients With Alzheimer’s Disease

Claire Murphy and Paul E. Gilbert

Part V Treatment Options

24 Treatment of Alzheimer’s Disease: Basic Considerations

Brigitte Zoeller Richter and Ralph W. Richter

25 Donepezil in Treatment of AD

Ging-Yuek Robin Hsiung and Howard Feldman

26 Rivastigmine for Treatment of AD

Martin R. Farlow

27 Galantamine in Treatment of AD

M. Saleem Ismail and Pierre N. Tariot

28 Memantine in Treatment of AD

Hans Jörg Möbius

29 Alternative Treatment Options

Brigitte Zoeller Richter

Part VI Late-Stage Therapy

30 Pain and Palliative Care in Late-Stage Dementia Patients

Sophie Pautex, Dina Zekry, Gilbert Zulian, Gabriel Gold,

and Jean-Pierre Michel

31 Cardiological Issues in Late-Stage Alzheimer’s Disease:

A Clinician’s Approach

José R. Medina

Part VII Prevention Strategies

32 Neuroprotection and Neurodegenerative Disease

Frank John Emery Vajda

33 Neurotrophic Factors for Prevention of Alzheimer’s Disease

Mark H. Tuszynski

34 Statins in Prevention and Treatment of Alzheimer’s Disease

David A. Drachman

35 Potential Role of Androgens and Androgen Receptors

in Alzheimer’s Disease

Jacob Raber

36 Role of Nutrition in Prevention or Delay of Alzheimer’s Disease

Hannes B. Staehelin

37 Impact of Physical Activity on Prevention of Alzheimer’s Disease

Danielle Laurin, René Verreault, and Joan Lindsay

Part VIII Future Developments

38 Stem Cell Therapy for Alzheimer’s Disease

Kiminobu Sugaya

39 Secretases as